Effect of Repeated Intense Foveal Red-Light Therapy in Children with Pre-Myopia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Leber MHM, Milbradt TL, Fujimura AY, Silva YP, Amaral DC, Leber HM, Belfort R
Current eye research · 1 cita
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2025-06-17 · Curr Eye Res · vol. 50 · número 11 · págs. 1085–1093
- Editorial
- Taylor & Francis
- Citado
- 11 citas · más que el 92% de estudios similares · 2.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- De pago · PUBLIC-DOMAIN
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Retinal Diseases and Treatments · Retinopathy of Prematurity Studies
- Palabras clave
- Medicine, Meta-analysis, Ophthalmology, Cochrane Library, Incidence (geometry), Randomized controlled trial, Population, Internal medicine
- MeSH
- fovea centralis, humans, myopia, refraction, ocular, phototherapy, visual acuity, child, randomized controlled trials as topic, axial length, eye
7 autores
- Matheus Henrique Monteiro Leber🇧🇷 · autor de correspondenciaUniversidade Federal de Santa Maria
- Tanize Louize Milbradt🇧🇷Universidade Federal de Santa Maria
- Alexandre Yamada Fujimura🇧🇷Faculdade de Medicina de Marília
- Yasmin Picanço Silva🇭🇺University of Debrecen
- Dillan Cunha Amaral🇧🇷Universidade Federal do Rio de Janeiro
- Henrique Monteiro Leber🇧🇷Fundação Técnico Educacional Souza Marques
- Rubens Belfort Neto🇧🇷Instituto da Visão; Universidade Federal de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Myopia is a significant public health concern with increased risk of ocular complications. Intense Foveal Red Light (IFRL) therapy has been explored in myopia control, but its efficacy at the pre-myopic stage remains underexplored. The use of this therapy in a population without a myopia diagnosis may offer a new window for the prophylactic application of IFRL therapy. The purpose of this meta-analysis is to determine the effectiveness of IFRL therapy in children with pre-myopia.
Methods
PubMed, Embase, and the Cochrane Library were systematically searched for studies investigating the effects of IFRL therapy on myopia incidence, changes in axial length (AL), choroidal thickness (CT), and cycloplegic spherical equivalent refraction (SER). Two independent reviewers screened studies, extracted data, and assessed the risk of bias. Meta-analyses were conducted using random-effects models to estimate the pooled effect sizes.
Results
Of 365 studies identified, 4 met the criteria, totaling 619 participants (mean age 8.48 years, 51.8% female). At 6 months, IFRL significantly reduced myopia incidence (Risk Difference [RD] - 0.1; 95% CI -0.15 to -0.05; p p p p p p p < 0.01).
Conclusion
IFRL effectively reduced myopia incidence, AL, and improved SER and CT. These findings support further research on its long-term efficacy and safety, particularly regarding potential adverse effects and durability of outcomes. Overall, IFRL may offer a preventive strategy for pre-myopic children.
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