Early changes in choroidal thickness and ocular biometry in predicting who will achieve full myopia control with repeated low-level red light therapy
Chen Y, Li M, Shang X, Li G, Zhao Z, Li P, Liu Y, Xiong R, Lai M, Wang Y, He M, Zhu Z
Photodiagnosis and photodynamic therapy · 2 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- University Grants Committee
- Subvenciones
- University Grants Committee (P0048638); University Grants Committee (P0048181)
Según 1 financiador declarado.
Publicación
- Publicado
- 2025-06-16 · Photodiagnosis Photodyn Ther · vol. 54 · pág. 104672
- Editorial
- Elsevier BV
- Citado
- 4 citas · más que el 89% de estudios similares · 2.5× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Retinopathy of Prematurity Studies · Retinal Diseases and Treatments
- Palabras clave
- Ophthalmology, Medicine, Optometry
- MeSH
- choroid, humans, myopia, photochemotherapy, biometry, child, female, male
12 autores
- Yanxian Chen🇭🇰Hong Kong Polytechnic University
- Mingge Li🇨🇳Shenzhen Sixth People's Hospital; ShenZhen People’s Hospital
- Xianwen Shang🇭🇰Hong Kong Polytechnic University
- Guangyu Li🇭🇰Hong Kong Polytechnic University
- Ziwei Zhao🇭🇰Hong Kong Polytechnic University
- Pengju Li🇭🇰Hong Kong Polytechnic University
- Yan‐Jun Liu🇭🇰Hong Kong Polytechnic University
- Ruilin Xiong🇨🇳Sun Yat-sen University
- Mengying Lai🇭🇰Hong Kong Polytechnic University
- Yueye Wang🇭🇰Hong Kong Polytechnic University
- Mingguang He🇭🇰 · autor de correspondenciaHong Kong Polytechnic University
- Zhuoting Zhu🇦🇺 · autor de correspondenciaCentre for Eye Research Australia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To evaluate the early predictors for achieving full myopia control with repeated low-level red light (RLRL) therapy based on two independent randomized clinical trials (RCTs).
Methods
Myopic children undergoing RLRL therapy from a multi-center RCT (training set) and a single-center RCT (validation set) were included. Full myopia control was defined as axial elongation <0.1mm/year. Variables included age, sex, baseline refraction, ocular parameters at baseline, 1 and 3 months (axial length [AL] and subfoveal choroidal thickness [sChT]), as well as their rates of change over the first 3 months. Four random forest models to predict full myopia control after 1 year and a logistic regression was used to estimate 2-year outcome.
Results
A total of 148 children were analyzed. The proportions of 1-year full myopia control was 54.2 % of eyes in the training set and 55.0 % in the validation set. Random forest models incorporating the rate of change in AL and sChT showed high predictive accuracy (AUC: 0.97 to 0.98) in external validation. The rate of change in AL contributed the most for model accuracy. For 2-year control, the rate of AL change had an AUC of 0.99 while the rate of change in sChT achieved only 0.69.
Conclusions
The rate of change in AL during the first three months emerged as the most important predictor for treatment outcomes at both 1-year and 2-year, rather than the change in sChT. Early monitoring of AL changes could be a valuable tool for identifying children most likely to benefit from this intervention.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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