Efficacy and safety of time-restricted eating in metabolic dysfunction-associated steatotic liver disease
Oh JH, Yoon EL, Park H, Lee S, Jo AJ, Cho S, Kwon E, Nah EH, Lee JH, Park JH, Ahn SB, Jun DW
Journal of hepatology · 15 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Korea National Institute of Health
- Subvenciones
- Korea National Institute of Health (2022-ER0906-02)
Según 1 financiador declarado.
Publicación
- Publicado
- 2025-06-19 · J Hepatol · vol. 83 · número 6 · págs. 1256–1265
- Editorial
- Elsevier BV
- Citado
- 29 citas · más que el 99% de estudios similares · 15.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Liver Disease Diagnosis and Treatment · Bariatric Surgery and Outcomes
- Palabras clave
- time-restricted eating, non-alcoholic fatty liver disease, caloric restriction, hepatic steatosis, weight loss, body composition, insulin resistance, glucose homeostasis, liver fibrosis, sleep quality, obesity, overweight, dietary intervention, proton density fat fraction, liver stiffness, lipid profile, safety and tolerability
- MeSH
- humans, fatty liver, insulin resistance, obesity, weight loss, treatment outcome, caloric restriction, body composition, time factors, adult, middle aged, female, male, overweight
12 autores
- Joo Hyun Oh🇰🇷Eulji University; CHA University Bundang Medical Center; CHA University
- Eileen Laureal Yoon🇰🇷Hanyang University
- Huiyul Park🇰🇷Hanyang University
- Seungmin Lee🇰🇷Sungshin Women's University
- Ae Jeong Jo🇰🇷Gyeongkuk National University
- Seon Cho🇰🇷Korea Association of Health Promotion
- Eunjoo Kwon🇰🇷Korea Association of Health Promotion
- Eun‐Hee Nah🇰🇷Chonnam National University; Chonnam National University Hospital
- Jun Hyuk Lee🇰🇷Eulji University; Eulji Medical Center
- Jung Hwan Park🇰🇷Hanyang University
- Sang Bong Ahn🇰🇷 · autor de correspondenciaEulji University; Eulji Medical Center
- Dae Won Jun🇰🇷 · autor de correspondenciaHanyang University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background & aims
Time-restricted eating (TRE) may improve weight loss, insulin resistance, and body composition, which are key factors in the pathophysiology of metabolic dysfunction-associated steatotic liver disease (MASLD). However, evidence on the efficacy of TRE in patients with MASLD is limited. This study aimed to evaluate the potential benefits of TRE in patients with overweight or obesity and MASLD.
Methods
In this 16-week randomized controlled trial, patients with overweight or obesity and MASLD were randomized into three groups in a 1:1:1 ratio: standard of care (SOC), calorie restriction (CR), and TRE. The primary endpoint was an improvement in hepatic steatosis, measured using MRI-proton density fat fraction. Changes in liver fibrosis, body composition, lipid profiles, glucose homeostasis, and sleep quality were also analyzed.
Results
Among the 337 participants randomized, 333 were included in the full analysis set (113 in SOC, 110 in CR, and 110 in TRE). After the 16-week intervention, hepatic steatosis significantly decreased in the TRE group (-25.8%) compared to the SOC group (0.7%, p 0.999). The TRE group also showed greater reductions in body weight, waist circumference, and body fat mass compared to the SOC group, while changes were comparable between TRE and CR. Liver stiffness, glucose homeostasis, and sleep quality were similar between the TRE and CR groups. No serious adverse events were reported.
Conclusions
TRE effectively reduces hepatic steatosis in MASLD, with comparable benefits on weight loss, body composition, and metabolic parameters as CR. This approach may serve as a practical dietary strategy for MASLD management. ClinicalTrals.gov: NCT05579158.
Impact and implications
The efficacy of time-restricted eating in managing metabolic dysfunction-associated steatotic liver disease (MASLD) remains uncertain despite its potential metabolic benefits. This 16-week randomized controlled trial compared the effects of time-restricted eating, calorie restriction, and standard of care on hepatic steatosis and metabolic outcomes in patients with MASLD. Time-restricted eating effectively reduces hepatic steatosis in MASLD, with comparable benefits on weight loss, body composition, and metabolic parameters as calorie restriction. Time-restricted eating may serve as a practical dietary strategy for MASLD management, warranting further long-term investigations.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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