Financiado en parte por Novo Nordisk
Time-Restricted Eating and Sleep, Mood, and Quality of Life in Adults With Overweight or Obesity: A Secondary Analysis of a Randomized Clinical Trial
Clavero-Jimeno A, Dote-Montero M, Migueles JH, Camacho-Cardenosa A, Medrano M, Alfaro-Magallanes VM, Osés M, Carneiro-Barrera A, de Cabo R, Muñoz-Torres M, Labayen I, Ruiz JR
JAMA network open · 9 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- Ministerio de Ciencia, Innovación y Universidades
- Gobierno
- Consejería de Transformación Económica, Industria, Conocimiento y Universidades
- Gobierno
- European Commission
- Empresa
- Novo Nordisk
- Gobierno
- Ministerio de Ciencia e Innovación
- Universidad u hospital
- Universidad de Granada
- Universidad u hospital
- Universidad Pública de Navarra
- Gobierno
- Junta de Andalucía
- Gobierno
- Gobierno de Navarra
- Gobierno
- European Regional Development Fund
- Gobierno
- Agencia Estatal de Investigación
- Gobierno
- Ministerio de Universidades
- Gobierno
- NextGenerationEU
- Subvenciones
- Ministerio de Ciencia e Innovación (PID2022.141506OB.I00); Ministerio de Ciencia, Innovación y Universidades (10.13039.501100011033); Ministerio de Ciencia, Innovación y Universidades (FPU18/03357); Agencia Estatal de Investigación (AEI//10.13039/501100011033/); European Regional Development Fund (UGR20); Ministerio de Ciencia e Innovación (.13039/501100011033); Agencia Estatal de Investigación (501100011033); Ministerio de Ciencia e Innovación (10.13039); Ministerio de Ciencia, Innovación y Universidades (BG22/00075); European Commission (10.13039/501100011033); Agencia Estatal de Investigación (10.13039/501100011033); Agencia Estatal de Investigación (13039); European Commission (13039/501100011033); European Commission (501100011033); European Regional Development Fund (10.13039/501100011033); Agencia Estatal de Investigación (.13039/501100011033); Ministerio de Ciencia e Innovación (10.13039/501100011033/); European Regional Development Fund (13039/501100011033); Junta de Andalucía (UGR20); Consejería de Transformación Económica, Industria, Conocimiento y Universidades (A-CTS-516-UGR20); Agencia Estatal de Investigación (10.13039); Ministerio de Ciencia e Innovación (501100011033); European Regional Development Fund (501100011033); Universidad de Granada (FPU18); European Commission (UGR20); Ministerio de Ciencia, Innovación y Universidades (10.13039); Ministerio de Ciencia, Innovación y Universidades (.13039/501100011033); Ministerio de Ciencia, Innovación y Universidades (501100011033); Ministerio de Ciencia e Innovación (PID2022); Ministerio de Ciencia e Innovación (/AEI/10.13039/ 501100011033)
Según 13 financiadores declarados.
Publicación
- Publicado
- 2025-06-25 · JAMA Netw Open · vol. 8 · número 6 · pág. e2517268
- Editorial
- American Medical Association
- Citado
- 16 citas · más que el 98% de estudios similares · 8.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Sleep and related disorders · Nutritional Studies and Diet
- Palabras clave
- time-restricted eating, obesity, overweight, sleep, mood, quality of life, depression, anxiety, stress, adults with obesity, weight management interventions, circadian rhythm, sleep disorders, eating disorders, eating disorder treatment
- MeSH
- humans, obesity, fasting, feeding behavior, affect, sleep, diet, mediterranean, time factors, quality of life, adult, middle aged, spain, female, male, overweight
12 autores
- Antonio Clavero‐Jimeno🇪🇸 · autor de correspondenciaUniversidad de Granada
- Manuel Dote‐Montero🇺🇸🇪🇸National Institutes of Health; Universidad de Granada; National Institute of Diabetes and Digestive and Kidney Diseases
- Jairo H. Migueles🇪🇸Universidad de Granada
- Alba Camacho-Cardeñosa🇪🇸Universidad de Granada; Instituto de Investigación Biosanitaria de Granada
- María Medrano🇪🇸Universidad Pública de Navarra (UPNA); Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Navarre Institute of Health Research; Centro de Investigación Biomédica en Red
- Víctor Manuel Alfaro-Magallanes🇪🇸Universidad Pública de Navarra (UPNA); Navarre Institute of Health Research; Universidad Politécnica de Madrid
- Maddi Osés🇪🇸Universidad Pública de Navarra (UPNA); Navarre Institute of Health Research
- Almudena Carneiro‐Barrera🇪🇸Universidad Loyola Andalucía; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Centro de Investigación Biomédica en Red
- Rafael de Cabo🇺🇸National Institutes of Health; National Institute on Aging
- Manuel Muñoz‐Torres🇪🇸Universidad de Granada; Instituto de Salud Carlos III; Instituto de Investigación Biosanitaria de Granada; Centro de Investigación Biomédica en Red; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
- Idoia Labayen🇪🇸Universidad Pública de Navarra (UPNA); Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Navarre Institute of Health Research; Centro de Investigación Biomédica en Red
- Jonatan R. Ruiz🇪🇸 · autor de correspondenciaUniversidad de Granada; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Instituto de Investigación Biosanitaria de Granada; Centro de Investigación Biomédica en Red
Resumen
El texto original del estudio, en el idioma en que se publicó.
Importance
It remains largely unknown whether the timing of the eating window during time-restricted eating (TRE) affects sleep, mood, and quality of life differently.
Objective
To investigate whether 3 TRE schedules-an 8-hour eating window in the early part of the day, the late part of the day, or selected by the participant-combined with usual care (UC; a Mediterranean diet education program) were associated with changes in sleep, mood, and quality of life compared with UC alone in adults with overweight or obesity over a 12-week intervention.
Design, setting, and participants
This was a prespecified secondary analysis of a parallel-group randomized clinical trial conducted from April 11, 2022, to March 6, 2023, in Granada (southern Spain) and Pamplona (northern Spain). Eligible participants were men and women aged 30 to 60 years with overweight or obesity. Data analyses for the current study were performed between March 14, 2024, and December 5, 2024.
Intervention
Participants in the UC group maintained their usual eating window (≥12 hours daily) and received an educational program based on the Mediterranean diet. Participants in the early TRE group had an 8-hour eating window starting before 10 am and the late TRE group, after 1 pm; self-selected TRE participants chose their own 8-hour window. All TRE participants also received the UC educational program. Group allocation was 1:1:1:1.
Main outcomes and measures
Changes in sleep were objectively assessed using accelerometry for 2 weeks before the intervention and during the final 2 weeks of the intervention. Changes in mood dimensions-depression, anxiety, and stress-and quality of life were assessed before and after the 12-week intervention using self-administered questionnaires.
Results
A total of 197 participants (98 women [49.7%]; mean [SD] age, 46.1 [8.4] years; mean [SD] body mass index, 32.8 [3.2], calculated as weight in kilograms divided by height in meters squared) were randomized to UC (n = 49), early TRE (n = 49), late TRE (n = 52), and self-selected TRE (n = 47). No significant differences were observed between the early TRE and UC groups for sleep (eg, mean difference in total sleep time, 0.2 [95% CI, -0.2 to 0.6] hours), mood (eg, mean difference in Beck Depression Inventory Fast Screen score, 0.2 [95% CI, -1.0 to 1.3] points; mean difference in state anxiety score on the State-Trait Anxiety Inventory, -1.2 [95% CI, -6.4 to 4.1] points; mean difference in Perceived Stress Scale score, 2.1 [95% CI, -1.8 to 5.9] points), and quality of life (eg, mean difference in general health score on the Rand 36-Item Short Form Health Survey, 3.3 [95% CI, -4.4 to 10.9] points). Results were also nonsignificant for the late TRE and self-selected TRE groups compared with the UC group as well as between the TRE groups.
Conclusions and relevance
In this secondary analysis of a randomized clinical trial of 3 different TRE schedules, incorporating TRE into a UC intervention, regardless of the eating window timing, was not associated with significant changes in sleep, mood, or quality of life compared with UC alone in adults with overweight or obesity. The findings suggest TRE may be a viable nutritional weight management strategy without adverse effects on sleep, mood, or quality of life.
Trial registration
ClinicalTrials.gov Identifier: NCT05310721.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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