Music interventions in 132 healthy older adults enhance cerebellar grey matter and auditory working memory, despite general brain atrophy
Marie D, Müller CAH, Altenmüller E, Van De Ville D, Jünemann K, Scholz DS, Krüger THC, Worschech F, Kliegel M, Sinke C, James CE
Neuroimage. Reports · 18 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Science Foundation
- Gobierno
- Deutsche Forschungsgemeinschaft
- Gobierno
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Gobierno
- Swiss National Science Foundation
- Gobierno
- German Research Foundation
- Subvenciones
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (170410); Deutsche Forschungsgemeinschaft (323965454)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2023-03-23 · Neuroimage Rep · vol. 3 · número 2 · pág. 100166
- Editorial
- Elsevier BV
- Citado
- 42 citas · más que el 97% de estudios similares · 5.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 147 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Neuroscience and Music Perception · Hearing Loss and Rehabilitation · Hearing, Cochlea, Tinnitus, Genetics
- Palabras clave
- Working memory, Psychology, Audiology, Context (archaeology), Grey matter, Voxel-based morphometry, Cognition, Neuroplasticity, Effects of sleep deprivation on cognitive performance, Neuroscience, Cognitive psychology, Medicine, White matter, Magnetic resonance imaging
11 autores
- Damien Marié🇨🇭 · autor de correspondenciaUniversity of Geneva; HES-SO University of Applied Sciences and Arts Western Switzerland; Centre d'Imagerie BioMedicale
- Cécile A. H. Müller🇨🇭University of Geneva; HES-SO University of Applied Sciences and Arts Western Switzerland
- ECKART O. ALTENMÜLLER🇩🇪Hanover University of Music Drama and Media
- Dimitri Van De Ville🇨🇭University of Geneva; Centre d'Imagerie BioMedicale; École Polytechnique Fédérale de Lausanne
- Kristin Jünemann🇩🇪Medizinische Hochschule Hannover
- Daniel S. Scholz🇩🇪Hanover University of Music Drama and Media
- Tillmann H. C. Krüger🇩🇪Medizinische Hochschule Hannover
- Florian Worschech🇩🇪Hanover University of Music Drama and Media
- Matthias Kliegel🇨🇭University of Geneva
- Christopher Sinke🇩🇪Medizinische Hochschule Hannover
- Clara Eline James🇨🇭 · autor de correspondenciaUniversity of Geneva; HES-SO University of Applied Sciences and Arts Western Switzerland
Resumen
El texto original del estudio, en el idioma en que se publicó.
Normal aging is associated with brain atrophy and cognitive decline. Working memory, involved in cognitive functioning and daily living, is particularly affected. Music training gained momentum in research on brain plasticity and possible transfer effects of interventions on working memory, especially in the context of healthy aging. This longitudinal voxel-based morphometry study evaluated effects of 6-month music interventions on grey matter volume plasticity and auditory working memory performance in 132 healthy older adults. This study is part of a randomized controlled trial comparing two interventions: piano practice (experimental group) and musical culture (musical listening awareness, active control). We report significant grey matter volume increase at whole-brain level in the caudate nucleus, Rolandic operculum and inferior cerebellum when merging both groups, but no group differences. Cerebellar grey matter increase, training intensity metrics and sleep were positively associated with tonal working memory improvement. Digit Span Backward verbal working memory performance also increased. Using region of interest analyses, we showed a group difference in the right primary auditory cortex grey matter volume, decreasing in the musical group while staying stable in the piano group. In contrast, a significant 6-month whole-brain atrophy pattern consistent with longer-term investigations of the aging brain was revealed. We argue that education for seniors should become a major policy priority in the framework of healthy aging, to promote brain plasticity and cognitive reserve, through stimulating group interventions such as music-making and active listening.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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