Efficacy and safety of eight-week therapy with Ashwagandha root extract in improvement of sexual health in healthy men: Findings of a prospective, randomized, double-blind, placebo-controlled study
Mutha AS, Mutha SA, Tejuja AH, Beldar AS, Mulay AM, Langade D
Journal of Ayurveda and integrative medicine · 2 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-07-01 · J Ayurveda Integr Med · vol. 16 · número 4 · pág. 101155
- Editorial
- Elsevier BV
- Citado
- 7 citas · más que el 97% de estudios similares · 8.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Phytochemicals and Medicinal Plants · Phytochemistry and Bioactive Compounds · Complementary and Alternative Medicine Studies
- Palabras clave
- Medicine, Placebo, Double blind, Randomized controlled trial, Physical therapy, Traditional medicine, Internal medicine, Alternative medicine
6 autores
- Amit Shrenikraj Mutha🇮🇳 · autor de correspondenciaGrant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals
- Sonali Amit Mutha
- Anupama Hem Tejuja
- Amit Shashikant Beldar🇮🇳Dr. D. Y. Patil Medical College, Hospital and Research Centre
- Alok Mahendra Mulay🇮🇳Grant Medical College and Sir Jamshedjee Jeejeebhoy Group of Hospitals
- Deepak Langade🇮🇳D.Y. Patil University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Ashwagandha, a traditional Indian Ayurvedic remedy, an adaptogen, may improve sexual dysfunction in men and women.
Objective
This 8-week prospective, double-blind, randomized, placebo-controlled study evaluated the efficacy and safety of Ashwagandha Root Extract (ARE) on improving sexual health in healthy adult men.
Method
A total of 100 healthy men aged 30-50 years were randomly assigned to receive ARE 300 mg twice daily (n = 50), or identical placebo (n = 50) in a 1:1 ratio for 8 weeks. Study assessments such as Satisfying Sexual Events (SSEs), the Sexual Desire Inventory (SDI-2), the International Index of Erectile Function (IIEF) score, semen parameters and the Quality of Life (QOL) were done using the SF-12 tool at baseline, week 2, week 4, and week 8. Three participants from ARE and four participants from the placebo group were excluded due to follow-up loss. The efficacy analyses were done on Per-Protocol (PP) dataset of 93, whereas safety analyses were done on all 100 participants.
Results
Significant improvements were observed with ARE for semen volume (p = 0.005), sperm number (p = 0.006), sperm concentration (p = 0.007), and sperm morphology (p = 0.007). The improvement in scores was better with ARE for SDI-2 (p < 0.05), orgasm and sexual desire domains of IIEF (p < 0.05), and SF-12 (p < 0.0001). No adverse events were reported in the study.
Conclusion
Ashwagandha improved the orgasmic function, sexual desire and overall sexual satisfaction with the 8-week of oral administration. It was well tolerated as it showed no significant changes in hepatic and renal parameters in blood.
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