Efficacy comparison of atropine, orthokeratology and repeated low-level red-light therapy for myopia control in children: a systematic review and network meta-analysis
Zheng Z, Jiang X, Chen R, Dong L
The British journal of ophthalmology · 8 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Universidad u hospital
- Beijing Tongren Hospital
- Gobierno
- R&D Program of Beijing Municipal Education Commission
- Subvenciones
- Beijing Tongren Hospital (No. 2023-YJJ-ZZL-003); National Natural Science Foundation of China (82401283)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2025-07-03 · Br J Ophthalmol · vol. 109 · número 11 · págs. 1215–1220
- Editorial
- BMJ
- Citado
- 19 citas · más que el 97% de estudios similares · 5.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Ophthalmology and Visual Impairment Studies · Corneal surgery and disorders · Retinopathy of Prematurity Studies
- Palabras clave
- Medicine, Orthokeratology, Meta-analysis, Randomized controlled trial, Atropine, Ophthalmology, Confidence interval, Internal medicine
- MeSH
- humans, myopia, atropine, mydriatics, refraction, ocular, treatment outcome, child, randomized controlled trials as topic, orthokeratologic procedures, low-level light therapy
4 autores
- Zetong Zheng🇨🇳Capital Medical University
- Xue Jiang🇨🇳Beijing Tongren Hospital; Capital Medical University; Ministry of Industry and Information Technology
- Rongxin Chen🇨🇳Capital Medical University
- Dong Li🇨🇳 · autor de correspondenciaBeijing Tongren Hospital; Capital Medical University; Ministry of Industry and Information Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
This study aimed to compare the efficacy of different interventions for myopia control in children, including 0.01% atropine (AP), orthokeratology (Ortho-k), and repeated low-level red-light therapy (RLRL), and their combinations by conducting a network meta-analysis.
Methods
We searched for randomised controlled trials (RCTs) in PubMed, Web of Science and Embase. The primary outcomes were the mean changes in the cycloplegic spherical equivalent (SE) and axial length (AL) at the 12-month follow-up. A Bayesian random-effects network meta-analysis was performed to estimate pooled weighted mean differences and 95% credible intervals.
Results
The analysis included 41 RCTs with 6434 eyes. Compared with the control group, all interventions were found to be effective at slowing myopia progression, combining direct and indirect evidence at the 12-month follow-up: RLRL therapy (AL -0.31 (0.39, 0.24), p<0.05; SE 0.76 (0.54, 0.98), p<0.05), 0.01% atropine (AL -0.13 (-0.20, 0.07), p<0.05; SE 0.25 (0.08, 0.42), p<0.05), Ortho-k therapy (AL -0.16 (-0.26, 0.06), p<0.05; SE 0.58 (0.05, 1.13), p<0.05) and 0.01% atropine+Ortho-k therapy (AL -0.27 (-0.38, 0.16), p<0.05; SE 0.76 (0.23, 1.31), p<0.05). The cumulative probability ranking suggested that RLRL therapy was the most effective intervention in slowing AL, followed by 0.01% atropine+Ortho-k, Ortho-k and 0.01% atropine.
Conclusions
This network meta-analysis provides evidence that RLRL, 0.01% atropine, Ortho-k and 0.01% atropine+Ortho-k are all effective in suppressing myopia progress. In terms of long-term treatment efficacy in slowing AL and SE procession, RLRL was the most effective intervention.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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