Financiado en parte por DuPont
Ageing modifies the oral microbiome, nitric oxide bioavailability and vascular responses to dietary nitrate supplementation
Vanhatalo A, L'Heureux JE, Black MI, Blackwell JR, Aizawa K, Thompson C, Williams DW, van der Giezen M, Winyard PG, Jones AM
Free radical biology & medicine · 5 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- DuPont
- Organización sin fines de lucro
- Wellcome Trust
- Universidad u hospital
- University of Exeter
- Gobierno
- Directorate for Biological Sciences
- Gobierno
- Medical Research Council
- Gobierno
- Biotechnology and Biological Sciences Research Council
- Subvenciones
- Biotechnology and Biological Sciences Research Council (WT101650MA); Biotechnology and Biological Sciences Research Council (BB/P022162/1); Biotechnology and Biological Sciences Research Council (BB/K003240); Biotechnology and Biological Sciences Research Council (BB/K003240/1); Medical Research Council (WT101650MA); Wellcome Trust (WT101650MA); Wellcome Trust (WT097835MF); Biotechnology and Biological Sciences Research Council (WT097835MF); Medical Research Council (M008924); Medical Research Council (MR/M008924/1); Medical Research Council (WT097835MF)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2025-07-03 · Free Radic Biol Med · vol. 238 · págs. 682–696
- Editorial
- Elsevier BV
- Citado
- 12 citas · más que el 98% de estudios similares · 9.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Oral microbiology and periodontitis research · Cardiovascular Health and Disease Prevention · Nitric Oxide and Endothelin Effects
- Palabras clave
- oral microbiota, dietary nitrate, beetroot juice, antiseptic mouthwash, aging, nitric oxide bioavailability, vascular function, blood pressure, flow-mediated dilation, plasma nitrite, Prevotella, ammonia synthesis, older adults
- MeSH
- mouth, humans, beta vulgaris, nitrates, nitric oxide, mouthwashes, cross-over studies, double-blind method, biological availability, aging, dietary supplements, adolescent, adult, aged, female, male, young adult, microbiota, fruit and vegetable juices
10 autores
- Anni Vanhatalo🇬🇧 · autor de correspondenciaUniversity of Exeter
- Joanna E. L’Heureux🇬🇧University of Exeter
- Matthew I. Black🇬🇧University of Exeter
- Jamie R. Blackwell🇬🇧University of Exeter
- Kuni Aizawa🇬🇧University of Exeter; NIHR Exeter Clinical Research Facility
- Christopher Thompson🇬🇧University of Exeter
- David Wynne Williams🇬🇧Cardiff University
- Mark van der Giezen🇳🇴University of Stavanger
- Paul Graham Winyard🇬🇧University of Exeter
- ANDREW MARK JONES🇬🇧University of Exeter
Resumen
El texto original del estudio, en el idioma en que se publicó.
This study evaluated whether changes in the oral microbiome in response to dietary nitrate and antiseptic mouthwash treatments were related to changes in nitric oxide bioavailability and vascular function. Thirty-nine young (18-30 years) and thirty-six older (67-79 years) males and females completed a placebo-controlled, double-blind cross-over intervention including three 2-week conditions separated by 2-week washouts: placebo beetroot juice (PL), nitrate-rich beetroot juice (BR) and antiseptic mouthwash (MW). The oral microbiomes of young and older adults responded differently to BR (post BR non-metric multidimensional scaling P = 0.01), while the oral microbiomes of both age groups were unaffected by PL and MW interventions. Older people, who had elevated baseline mean arterial pressure (MAP; 95 ± 9 mmHg) compared to young adults (87 ± 7 mmHg, P 2-] r = -0.41, P = 0.02), which in turn correlated with decreases within the co-occurring module of bacteria dominated by the genus Prevotella (P. intermedia r = -0.72, P = 0.001; P. dentalis r = -0.88, P < 0.0001; Crassaminicella sp. SY095 r = -0.81, P < 0.0001). Greater blood pressure benefits from supplemental dietary nitrate in older compared to younger people are mediated primarily by the suppression of potentially harmful oral bacteria, that have been associated with ammonia production.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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