Financiado en parte por L'Oreal Dermatological Beauty China, SkinCeuticals
A Randomized, Investigator-Blinded, Split-Face, Controlled Trial Evaluating the Efficacy and Satisfaction of a Topical Product Containing Blueberry Extract and Pro-Xylane Combined With Micro-Focused Ultrasound for Anti-aging
Jiang X, Peng S, Chen Y, Nan Y, Song W
Journal of cosmetic dermatology · 3 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- L'Oreal Dermatological Beauty China, SkinCeuticals
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-07-01 · J Cosmet Dermatol · vol. 24 · número 7 · pág. e70281
- Editorial
- Wiley
- Citado
- 3 citas · más que el 89% de estudios similares · 2.4× el promedio de su campo
- Referencias
- 28 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Dermatologic Treatments and Research · Skin Protection and Aging · Facial Rejuvenation and Surgery Techniques
- Palabras clave
- blueberry extract, topical skin care, skin aging, anti-aging, skin elasticity, skin thickness, fine lines, skin roughness, transepidermal water loss, patient satisfaction, Global Aesthetic Improvement Scale
- MeSH
- face, humans, plant extracts, treatment outcome, combined modality therapy, ultrasonic therapy, administration, cutaneous, single-blind method, skin aging, elasticity, adolescent, adult, aged, middle aged, patient satisfaction, female, male, young adult, skin cream, blueberry plants
5 autores
- Xiaoling Jiang
- Shiqi Peng
- Ying Chen
- Yuqing Nan
- Weimin Song · autor de correspondencia
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Micro-focused ultrasound (MFUS) has been effective in treating skin aging, which manifests as skin thinning, reduced elasticity, wrinkling, etc. AIMS: This study aims to evaluate the efficacy and satisfaction of combining a product containing blueberry extract and Pro-xylane (A.G.E. cream) with MFUS in antiaging effects in the Chinese population.
Methods
In this randomized, investigator-blinded, controlled trial, patients aged 18-65 with skin roughness, sagging, laxity, or fine lines/wrinkles were enrolled. After MFUS, one side of patients' faces was randomly assigned to apply the A.G.E. cream and the other side with the standard moisturizer. Patients were followed up for 180 days. The primary endpoint was the Global Aesthetic Improvement Scale (GAIS). Secondary endpoints included percentage changes from baseline in fine lines, skin elasticity, dermal thickness, and transepidermal water loss. Patient and dermatologist satisfaction was evaluated using a questionnaire.
Results
A total of 50 patients were included in the study, with 49 (98%) being female. The mean ± SD age was 33.7 ± 6.4 years. For the primary endpoint, the intervention side demonstrated significant improvement in GAIS compared to the control side on Day 90 (p < 0.001). For secondary endpoints, the A.G.E. cream use after MFUS significantly improved skin elasticity at the cheeks and mouth corners on multiple follow-up days and improved fine lines at the mouth corners on Day 180. Patients and dermatologists reported higher satisfaction levels with the aesthetic outcomes of the intervention side.
Conclusions
The application of the A.G.E. cream following MFUS treatment improved skin elasticity, dermal thickness, fine lines, and patient/dermatologist satisfaction.
Trial registration
ClinicalTrials.gov identifier: NCT05748470.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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