Low apolipoprotein B and LDL-cholesterol are associated with the risk of cardiovascular and all-cause mortality: a prospective cohort
Yu X, Yuan Y, Dong X, Xier Z, Ma L, Peng H, Li G, Yang Y
Annals of medicine · 4 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Natural Science Foundation of Xinjiang Province
- Gobierno
- Natural Science Foundation of Xinjiang
- Gobierno
- Tianshan Talent Cultivation Program-High-Level Medical and Health Professionals Project, Xinjiang Uygur Autonomous Region
- Gobierno
- Tianshan Talent Cultivation Program Project of Xinjiang Uygur Autonomous Region
- Gobierno
- Natural Science Foundation of Xinjiang Uygur Autonomous Region
- Subvenciones
- Natural Science Foundation of Xinjiang Province (2023D01C91)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-07-11 · Ann Med · vol. 57 · número 1 · pág. 2529565
- Editorial
- Informa
- Citado
- 3 citas · más que el 90% de estudios similares · 2.6× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Lipoproteins and Cardiovascular Health · Diabetes, Cardiovascular Risks, and Lipoproteins · Cholesterol and Lipid Metabolism
- Palabras clave
- apolipoprotein B, LDL cholesterol, cardiovascular mortality, all-cause mortality, low LDL cholesterol, cardiovascular risk factors, NHANES, cerebrovascular disease, lipid biomarkers
- MeSH
- humans, cardiovascular diseases, apolipoproteins b, nutrition surveys, cause of death, proportional hazards models, risk factors, prospective studies, adult, aged, middle aged, female, male, cholesterol, ldl, apolipoprotein b-100, biomarkers
8 autores
- Xiaolin Yu🇨🇳People's Hospital of Xinjiang Uygur Autonomous Region
- Yujuan Yuan🇨🇳People's Hospital of Xinjiang Uygur Autonomous Region
- Xiangyu Dong🇨🇳People's Hospital of Xinjiang Uygur Autonomous Region
- Zulipiyemu Xier🇨🇳People's Hospital of Xinjiang Uygur Autonomous Region
- Ling Ma🇨🇳People's Hospital of Xinjiang Uygur Autonomous Region
- Hui Peng🇨🇳People's Hospital of Xinjiang Uygur Autonomous Region
- Guoqing Li🇨🇳 · autor de correspondenciaPeople's Hospital of Xinjiang Uygur Autonomous Region
- Yi‐Ning Yang🇨🇳 · autor de correspondenciaPeople's Hospital of Xinjiang Uygur Autonomous Region
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The association between low-density lipoprotein (LDL) cholesterol and increased mortality risk has been well-documented, yet apolipoprotein B (apoB) is regarded as a more precise risk indicator. However, a comprehensive analysis integrating both markers in relation to mortality risk remains unreported.
Objectives
This study aimed to investigate the relationship between LDL cholesterol levels and mortality across varying apoB concentrations within the general population.
Methods
Data from 15,380 participants in the 2005-2016 National Health and Nutrition Examination Survey (NHANES) were utilized to construct Cox regression models and apply restricted cubic splines, assessing the association between LDL cholesterol and mortality across distinct apoB stratifications.
Results
The study cohort had a median (IQR) age of 46.0 (32.0, 60.0) years, with 7949 (51.8%) males. During a median follow-up of 101.0 months (IQR: 67-137), 1771 (8.8%) all-cause mortality events were observed; 443 (2.1%) deaths were attributed to cardiovascular diseases, while 109 (0.5%) resulted from cerebrovascular diseases. Low apoB and LDL-cholesterol levels were independently linked to an elevated risk of all-cause and cardiovascular mortality. Compared with participants having apoB <90 mg/dL and LDL-cholesterol levels between 100-129 mg/dL, those with LDL-cholesterol <70 mg/dL (HR, 1.81; 95%CI: 1.39-2.36) and 70-99 mg/dL (HR, 1.28; 95%CI: 1.01-1.62) demonstrated a higher risk of all-cause mortality. Additionally, reduced apoB levels contributed to an increased risk of cardiovascular mortality among individuals with low LDL-cholesterol levels.
Conclusions
Low apoB and LDL-cholesterol levels were associated with heightened all-cause and cardiovascular mortality risk in the general population. Conversely, high apoB and low LDL-cholesterol levels did not correlate with increased mortality risk.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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