Effects of Creatine and β-Alanine Co-Supplementation on Exercise Performance and Body Composition: A Systematic Review
Ashtary-Larky D, Candow DG, Forbes SC, Hajizadeh L, Antonio J, Suzuki K
Nutrients · 5 citas
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- Revisión sistemática (indexado por PubMed)
- Estudiado en
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- Resultado principal
- Marcadores de salud y funcionamiento
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- Financiación independiente
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- Al menos un autor declara un vínculo económico con la industria
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Publicación
- Publicado
- 2025-06-21 · Nutrients · vol. 17 · número 13 · pág. 2074
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 7 citas · más que el 76% de estudios similares · 1.1× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Biochemical effects in animals · Sports Performance and Training
- Palabras clave
- creatine, beta-alanine, co-supplementation, dietary supplements, exercise performance, body composition, high-intensity exercise, anaerobic power, repeated bout effect, maximal strength, cardiorespiratory fitness, lean mass gain, fat mass reduction
- MeSH
- humans, creatine, beta-alanine, exercise, body composition, dietary supplements, adult, female, male, muscle strength, randomized controlled trials as topic, athletic performance
6 autores
- Damoon Ashtary‐Larky🇮🇷 · autor de correspondenciaAhvaz Jundishapur University of Medical Sciences
- Darren Glenn Candow🇨🇦University of Regina
- Scott C. Forbes🇨🇦Brandon University
- Leila Hajizadeh🇮🇷Islamic Azad University, Marvdasht
- José António🇺🇸Nova Southeastern University
- Katsuhiko Suzuki🇯🇵Waseda University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/Objectives: Creatine and β-alanine are two widely used dietary supplements known to enhance exercise performance and improve body composition; however, less is known regarding the synergistic effects of combining the two supplements. Methods: A systematic search was conducted across PubMed/MEDLINE, Scopus, and Web of Science databases for randomized controlled trials (RCTs) published up to March 2025. Eligible studies included adult participants receiving creatine and β-alanine together compared to creatine or β-alanine alone for at least four weeks and assessed measures of exercise performance and/or body composition. Study quality was assessed using the Cochrane Risk of Bias tool. Results: A total of 7 randomized controlled trials (n = 263 participants; 231 males and 32 females) met the inclusion criteria. Collectively, the combination of creatine and β-alanine supplementation enhanced high-intensity exercise performance, particularly anaerobic power and repeated-bout performance, compared to creatine or β-alanine alone. Co-ingestion of creatine and β-alanine supplementation did not increase measures of maximal strength compared to creatine alone. The effects of creatine and β-alanine supplementation on body composition were equivocal, with one study reporting greater lean mass gains and fat mass reductions compared to creatine and β-alanine supplementation individually, while another found no significant improvements. Additionally, no significant improvements in aerobic endurance capacity (VO2max, lactate threshold, or time to exhaustion) were observed from creatine and β-alanine supplementation co-ingestion. Conclusions: The combination of creatine and β-alanine supplementation may be effective for enhancing high-intensity exercise performance but has no greater effect on maximal strength, body composition, or measures of aerobic capacity compared to creatine or β-alanine alone.
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