Impact of almond milk fortified with vitamin D3-loaded soy protein nanoparticles on serum 25(OH)D3 concentrations in adults with CKD: a pilot double-blind randomized controlled trial
Kuo LY, Casta Neda BN, Luo YE, Aslan Ceylan J, Andrade JE, Andrade JM
Journal of nephrology · 0 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
- Universidad u hospital
- Institute of Food and Agricultural Sciences, University of Florida
- Gobierno
- Scientific and Technological Research Council of Turkey
- Subvenciones
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu (1059B192301773)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2025-07-12 · J Nephrol · vol. 38 · número 6 · págs. 1629–1638
- Editorial
- Springer Science+Business Media
- Citado
- 0 citas · más que el 20% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 29 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Parathyroid Disorders and Treatments · Dialysis and Renal Disease Management
- Palabras clave
- chronic kidney disease, vitamin D3, 25-hydroxyvitamin D3, almond milk, functional food fortification, vitamin D deficiency, serum calcium, parathyroid hormone, nanoparticle drug delivery
- MeSH
- humans, vitamin d deficiency, calcium, cholecalciferol, calcifediol, parathyroid hormone, soybean proteins, treatment outcome, pilot projects, double-blind method, food, fortified, adult, aged, middle aged, female, male, renal insufficiency, chronic, nanoparticles, biomarkers, prunus dulcis
8 autores
- Li‐Ying Kuo🇺🇸University of Florida
- Blanca Nuria Casta Neda🇺🇸University of Florida
- Yangyi E. Luo🇺🇸University of Florida
- Jiyan Aslan Ceylan🇹🇷🇺🇸Mardin Artuklu University; University of Florida
- Juan E. Andrade🇺🇸 · autor de correspondenciaUniversity of Florida
- Jeanette Andrade🇺🇸University of Florida
- Jeanette Andrade🇺🇸University of Florida
- Jeanette Andrade🇺🇸 · autor de correspondenciaUniversity of Florida
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Chronic kidney disease (CKD) impairs the activation of vitamin D, leading to deficiencies that exacerbate disease progression and metabolic complications. This pilot study investigated the effects of consuming almond milk fortified with vitamin D3 nanoparticles on 25(OH)D3 among adults with advanced stages of CKD.
Methods
A 21-day, double-blind randomized controlled pilot study was conducted. Participants (n = 18) were randomly assigned to consume 4 oz (118 ml) of almond milk daily with 4000 IU of vitamin D3 dispersed in soy protein nanoparticles (intervention group), or almond milk without vitamin D (control group). The primary outcome was the change in serum 25(OH)D3 levels, while secondary outcomes included changes in serum calcium and parathyroid hormone (PTH).
Results
From baseline to end of intervention, there was a significant decrease in serum 25(OH)D3 in the control group (49.2 ± 23.3 nmol/L to 44.5 ± 25.6 nmol/L; p 3. No differences between groups were observed in serum calcium and PTH.
Conclusion
The consumption of almond milk fortified with vitamin D3 dispersed in soy protein nanoparticles increased 25(OH)D3 in adults with advanced stages of CKD over 21-days. Future research should explore the metabolism and long-term efficacy of nanoparticle-based delivery of vitamin D3 in larger, more diverse populations.
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