Intermittent Fasting for the Prevention of Cardiovascular Disease Risks: Systematic Review and Network Meta-Analysis
Kibret KT, Peeters A, Tegegne TK, Mesfin YM, Nichols M
Current nutrition reports · 7 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Deakin University
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-07-24 · Curr Nutr Rep · vol. 14 · número 1 · pág. 93
- Editorial
- Springer Science+Business Media
- Citado
- 11 citas · más que el 87% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 92 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Nutritional Studies and Diet · Diet and metabolism studies
- Palabras clave
- intermittent fasting, cardiovascular risk, time-restricted eating, body weight, waist circumference, blood pressure, fasting blood glucose, fat-free mass, cardiovascular risk factors, lifestyle intervention
- MeSH
- humans, cardiovascular diseases, fasting, risk factors, blood pressure, adult, waist circumference, heart disease risk factors, intermittent fasting
5 autores
- Kelemu Tilahun Kibret🇦🇺 · autor de correspondenciaDeakin University
- Anna Peeters🇦🇺Deakin University; Victorian Health Promotion Foundation
- Teketo Kassaw Tegegne🇦🇺Deakin University
- Yonatan Moges Mesfin🇦🇺Murdoch Children's Research Institute
- Melanie S. Nichols🇦🇺Deakin University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
While several studies have assessed the potential effect of intermittent fasting on reducing cardiovascular risks, the findings are inconclusive.
Objective
To compare the relative effectiveness of intermittent fasting methods in reducing key cardiovascular risks.
Methods
Studies were searched from Medline, Embase, Cochrane Library Central and Global Health to identify studies that enrolled adults (≥ 18 years) to intermittent fasting methods and reported effects on one of the six specified cardiovascular risk factors. We performed a random-effects network meta-analysis using a frequentist framework. Outcomes were reported as mean differences (MD) with their corresponding 95% confidence intervals (CI).
Results
Fifty-six studies were included in the analysis. With high certainty of evidence, modified alternate-day fasting was found to be the most effective intervention compared to a usual diet in reducing body weight (MD= -5.18 kg; 95% CI: -7.04, -3.32), waist circumference (-3.55 cm; -5.66, -1.45), systolic blood pressure (-7.24 mmHg; -11.90, -2.58), diastolic blood pressure (-4.70 mmHg; -8.46, -0.95). With high certainty, time-restricted eating was the most effective intervention compared to usual diet in reducing fat-free mass (-0.82 kg; -1.46, -0.17), waist circumference (-3.00 cm; -4.50, -1.51), diastolic blood pressure (-3.24 mmHg; -4.69, -1.79) and fasting plasma glucose (-3.74 mg/dL; -6.01, -1.46).
Conclusions
Modified alternate-day fasting, and time-restricted eating appear to be promising approaches for reducing most cardiovascular risk factors. These intermittent fasting methods may be considered as potential components of lifestyle interventions aimed at managing cardiovascular disease risk factors. However, further long-term randomised controlled trials comparing intermittent fasting methods are needed to confirm their efficacy and assess their safety over time.
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