Serum albumin sensitization in children with cow's milk allergy: Clinical relevance to red meat reactions
Özdemiral C, Konuralp I, Sekerel BE
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 1 cita
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- Financiación independiente
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Publicación
- Publicado
- 2025-07-01 · Pediatr Allergy Immunol · vol. 36 · número 7 · pág. e70157
- Editorial
- Wiley
- Citado
- 3 citas · más que el 85% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Food Allergy and Anaphylaxis Research · Occupational exposure and asthma · Allergic Rhinitis and Sensitization
- Palabras clave
- Sensitization, Medicine, Allergy, Allergen, Clinical significance, Milk allergy, Cow's milk allergy, Food allergy, Immunology, Internal medicine
- MeSH
- animals, cattle, humans, food hypersensitivity, milk hypersensitivity, serum albumin, immunoglobulin e, allergens, prevalence, cross reactions, child, child, preschool, infant, female, male, red meat, clinical relevance
3 autores
- Cansu Özdemiral🇹🇷Hacettepe University
- Ilteber Konuralp🇹🇷Middle East Technical University
- Bülent Enis Şekerel🇹🇷 · autor de correspondenciaHacettepe University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Sensitization to serum albumins (SAs) in cow's milk allergy (CMA) may contribute to red meat (RM) allergy. This study evaluated the prevalence of SA sensitization, patterns of cross-sensitization, and clinical relevance to RM allergy in children with CMA.
Methods
Seventy children with CMA (58 current, 12 resolved) who underwent multiplex microarray testing were assessed for allergen sensitization profiles and reported reactions to RM.
Results
Bos d 6 sensitization was identified in 61.4% of patients, and 18% had been advised to avoid RM. Among Bos d 6-sensitized patients, 39.5% were monosensitized. Co-sensitization rates were 46.5% for Sus s 1, 25.5% for Equ c 3, 23.2% for Fel d 2, and 16.2% for Can f 3. A strong correlation was observed between Bos d 6 and Sus s 1 (r = .79), with moderate correlations to Equ c 3 and Can f 3. Hierarchical clustering grouped Bos d 6 with Sus s 1, Equ c 3, and Can f 3. While milk allergen sensitization decreased in the resolved-CMA group, Bos d 6 persisted in some patients. Although all children tolerated well-cooked RM, 10% reported allergic reactions via various exposure routes, including one patient with resolved-CMA. All RM-reactive patients were sensitized to Bos d 6.
Conclusions
Bos d 6 sensitization is common in children with CMA, yet clinical reactivity to RM is infrequent. Cultural and culinary practices may shape exposure and symptom expression, though avoidance behaviors remain common. Integrating allergen profiles into clinical care may guide risk stratification/avoidance recommendations.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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