Ultra-processed foods and non-alcoholic fatty liver disease: an updated systematic review and dose-response meta-analysis
Zhang J, Shu L, Chen X
Frontiers in nutrition · 7 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-07-11 · Front Nutr · vol. 12 · pág. 1631975
- Editorial
- Frontiers Media
- Citado
- 9 citas · más que el 90% de estudios similares · 2.6× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Liver Disease Diagnosis and Treatment · Diet, Metabolism, and Disease
- Palabras clave
- ultra-processed foods, non-alcoholic fatty liver disease, dietary intake, dose-response relationship, NAFLD risk factors, dietary habits, 24-hour dietary recall, cross-sectional study, sample size, subgroup analysis, nonlinearity, NAFLD severity, NAFLD progression
3 autores
- Jinghong Zhang🇨🇳Zhejiang Hospital
- Long Shu🇨🇳Zhejiang Hospital
- Xiaopei Chen🇨🇳 · autor de correspondenciaZhejiang Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Studies reported a significant association between ultra-processed food (UPF) consumption and increased risk of non-alcoholic fatty liver disease (NAFLD), but these have produced conflicting results. Thus, we conducted a systematic review and meta-analysis of existing observational studies to ascertain the association between UPF consumption and risk of NAFLD.
Methods
We systematically searched PubMed, Web of Science, Embase and China National Knowledge Infrastructure (CNKI) without language restrictions for eligible studies published from database inception until 31 March 2025. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were estimated using random-effects or fixed-effects models depending on heterogeneity.
Results
Overall, 10 articles involving 513,440 participants and 20,637 NAFLD cases were included. Highest UPF consumption was associated with a 22% increased risk of NAFLD compared to the lowest consumption (RR = 1.22, 95%CI: 1.14-1.31, p I 2 = 78.5%; P heterogeneity I 2 = 75.9%; p Pdose-response = 0.295, Pnonlinearity = 0.541). Subgroup analyses revealed the positive associations between UPF consumption risk of NAFLD in the subgroups of 24-h dietary recalls (RR = 1.35, 95%CI: 1.24-1.46, p p = 0.001) and sample sizep = 0.030), with less evidence of heterogeneity.
Conclusion
This study suggests that high UPF consumption is associated with an increased risk of NAFLD, albeit with substantial heterogeneity. Our findings underscore the importance of limiting UPF consumption in the prevention of NAFLD. Future studies with longitudinal designs are required to elucidate underlying mechanisms and confirm causality.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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