Effects of 4:3 Intermittent Fasting on Eating Behaviors and Appetite Hormones: A Secondary Analysis of a 12-Month Behavioral Weight Loss Intervention
Breit MJ, Caldwell AE, Ostendorf DM, Pan Z, Creasy SA, Swanson B, Clark K, Hill EB, MacLean PS, Bessesen DH, Melanson EL, Catenacci VA
Nutrients · 4 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Heart Association
- Gobierno
- National Institutes of Health
- Universidad u hospital
- Anschutz Medical Campus, University of Colorado
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (K01HL143039); National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK048520); National Institutes of Health (5r01dk111622-05); National Institutes of Health (AHA 23POST1022471); American Heart Association (R01 DK111622); American Heart Association (P30 DK048520); American Heart Association (UL1 TR002535); National Heart, Lung, and Blood Institute (K24 HL169755); National Institutes of Health (3p30dk048520-26s2); National Institutes of Health (UL1TR002535); American Heart Association (AHA 23POST1022471); National Institutes of Health (DK048520); National Institutes of Health (TR002535); National Institutes of Health (P30DK048520); National Institutes of Health (R01 DK111622, P30 DK048520, UL1 TR002535); National Institutes of Health (R01 DK111622)
Según 8 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-07-21 · Nutrients · vol. 17 · número 14 · pág. 2385
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 7 citas · más que el 94% de estudios similares · 3.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 58 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Eating Disorders and Behaviors · Regulation of Appetite and Obesity
- Palabras clave
- intermittent fasting, dietary habits, appetite-regulating hormones, binge eating, uncontrolled eating, emotional eating, cognitive restraint, weight loss, obesity, overweight, leptin, ghrelin, peptide YY, brain-derived neurotrophic factor, adiponectin, behavioral weight loss, caloric restriction, dietary flexibility, maladaptive eating
- MeSH
- humans, obesity, weight loss, peptide yy, leptin, brain-derived neurotrophic factor, exercise, caloric restriction, fasting, feeding behavior, appetite, adult, middle aged, female, male, overweight, adiponectin, ghrelin, weight reduction programs, intermittent fasting
12 autores
- Matthew J. Breit🇺🇸 · autor de correspondenciaUniversity of Colorado Anschutz
- Ann E. Caldwell🇺🇸University of Colorado Anschutz
- Danielle M. Ostendorf🇺🇸University of Colorado Anschutz
- Zhaoxing Pan🇺🇸University of Colorado Anschutz
- Seth A. Creasy🇺🇸University of Colorado Anschutz
- Bryan Swanson🇺🇸University of Colorado Anschutz
- Kevin Clark🇺🇸University of Colorado Anschutz
- Emily B. Hill🇺🇸University of Colorado Anschutz
- Paul S. MacLean🇺🇸University of Colorado Anschutz
- Daniel H. Bessesen🇺🇸University of Colorado Anschutz
- Edward L. Melanson🇺🇸University of Colorado Anschutz
- Victoria A. Catenacci🇺🇸University of Colorado Anschutz
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/objectives
Daily caloric restriction (DCR) is a common dietary weight loss strategy, but leads to metabolic and behavioral adaptations, including maladaptive eating behaviors and dysregulated appetite. Intermittent fasting (IMF) may mitigate these effects by offering diet flexibility during energy restriction. This secondary analysis compared changes in eating behaviors and appetite-related hormones between 4:3 intermittent fasting (4:3 IMF) and DCR and examined their association with weight loss over 12 months.
Methods
Adults with overweight or obesity were randomized to 4:3 IMF or DCR for 12 months. Both randomized groups received a matched targeted weekly dietary energy deficit (34%), comprehensive group-based behavioral support, and a prescription to increase moderate-intensity aerobic activity to 300 min/week. Eating behaviors were assessed using validated questionnaires at baseline and months 3, 6, and 12. Fasting levels of leptin, ghrelin, peptide YY, brain-derived neurotrophic factor, and adiponectin were measured at baseline and months 6 and 12. Linear mixed models and Pearson correlations were used to evaluate outcomes.
Results
Included in this analysis were 165 adults (mean ± SD; age 42 ± 9 years, BMI 34.2 ± 4.3 kg/m2, 74% female) randomized to 4:3 IMF (n = 84) or DCR (n = 81). At 12 months, binge eating and uncontrolled eating scores decreased in 4:3 IMF but increased in DCR (p p = 0.03), emotional eating (r = -0.37, p p < 0.01) at 12 months. There were no between-group differences in changes in fasting appetite-related hormones at any time point.
Conclusions
Compared to DCR, 4:3 IMF exhibited improved binge eating and uncontrolled eating behaviors at 12 months. This may, in part, explain the greater weight loss achieved by 4:3 IMF versus DCR. Future studies should examine mechanisms underlying eating behavior changes with 4:3 IMF and their long-term sustainability.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.