The association of ultra-processed food intake on age-related muscle conditions: a systematic review and dose-response meta-analysis with meta-regression
Hojjati Kermani MA, Awlqadr FH, Talebi S, Mehrabani S, Camera DM, Bagheri R, Poorbaferani F, Ghoreishy SM, Amirian P, Zarpoosh M, Moradi S
Journal of health, population, and nutrition · 6 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-07-30 · J Health Popul Nutr · vol. 44 · número 1 · pág. 271
- Editorial
- BioMed Central
- Citado
- 6 citas · más que el 83% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 137 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Food composition and properties · Nutritional Studies and Diet
- Palabras clave
- Meta-analysis, Meta-regression, Medicine, Environmental health, Epidemiology, Regression analysis, Internal medicine, Statistics, Mathematics
- MeSH
- muscle, skeletal, humans, diet, aging, aged, female, male, muscle strength, sarcopenia, fast foods, frailty, food, processed
11 autores
- Mohammad Ali Hojjati Kermani🇮🇷Masih Daneshvari Hospital; Shahid Beheshti University of Medical Sciences
- Farhang Hameed Awlqadr🇮🇶Sulaimani Polytechnic University
- Sepide Talebi🇮🇷University of Tehran
- Sanaz Mehrabani🇮🇷Isfahan University of Medical Sciences
- DONNY MICHAEL CAMERA🇦🇺Swinburne University of Technology
- Reza Bagheri🇮🇷University of Isfahan
- Fariborz Poorbaferani🇮🇷Isfahan University of Medical Sciences
- Seyed Mojtaba Ghoreishy🇮🇷Iran University of Medical Sciences
- Parsa Amirian🇮🇷Kermanshah University of Medical Sciences
- Mahsa Zarpoosh🇮🇷Kermanshah University of Medical Sciences
- Sajjad Moradi🇮🇷 · autor de correspondenciaUniversity of Maragheh; Maragheh University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Chronic excessive intake of ultra-processed foods (UPFs) has been linked to various metabolic conditions; however, its impact on skeletal muscle mass and function in older adults remains unclear. Therefore, we conducted this study to examine the association between UPF intake and age-related muscle outcomes, including frailty, sarcopenia, low muscle mass (LMM), and/or low muscle strength (LMS).
Methods
A systematic search was conducted in ISI Web of Science, LILACS, PubMed/MEDLINE, and Scopus without restrictions up to November 1, 2024. Relative risks (RRs) and 95% confidence intervals (CIs) were pooled using a random-effects model. Study quality and the presence of publication bias were assessed using the Newcastle-Ottawa Scale, Egger's regression asymmetry test, and Begg's rank correlation test.
Results
Data from 29 studies were included. Cohort studies showed that higher UPF intake was significantly associated with an increased risk of frailty (RR = 1.40; 95% CI 1.25-1.58; I2 = 83.0%; p 2 = 0.0%; p 2 = 85.1%; p = 0.016; n = 5). Non-linear dose-response analysis showed a positive linear association between UPF intake and frailty risk (P_non-linearity = 0.807; P_dose-response < 0.001; n = 5).
Conclusion
Higher UPF intake was associated with an increased risk of frailty in cohort studies and with low muscle strength in cross-sectional studies. These findings suggest that regular consumption of UPFs may negatively affect muscle health, potentially impairing quality of life and independence in older adults.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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