Ultraprocessed or minimally processed diets following healthy dietary guidelines on weight and cardiometabolic health: a randomized, crossover trial
Dicken SJ, Jassil FC, Brown A, Kalis M, Stanley C, Ranson C, Ruwona T, Qamar S, Buck C, Mallik R, Hamid N, Bird JM, Brown A, Norton B, Gandini Wheeler-Kingshott CAM, Hamer M, van Tulleken C, Hall KD, Fisher A, Makaronidis J, Batterham RL
Nature medicine · 88 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Cleveland Clinic
- Organización sin fines de lucro
- British Dietetic Association
- Gobierno
- National Institute for Health and Care Research
- Organización sin fines de lucro
- British Heart Foundation
- Organización sin fines de lucro
- Ataxia UK
- Organización sin fines de lucro
- Society for Endocrinology
- Gobierno
- European Commission
- Organización sin fines de lucro
- Rosetrees Trust
- Universidad u hospital
- University College London Hospitals NHS Foundation Trust
- Gobierno
- National Institutes of Health
- Gobierno
- Medical Research Council
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Institute for Health Research (NIHR)
- Gobierno
- EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)
- Subvenciones
- British Heart Foundation (SP/F/20/150002); Rosetrees Trust (PGL21/10079); Medical Research Council (MR/S026088/1); National Institutes of Health (945539); Rosetrees Trust (PGL22/100041); Medical Research Council (945539); Medical Research Council (MR/N013867/1); National Institute for Health and Care Research (NIHR303041)
Según 14 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-08-04 · Nat Med · vol. 31 · número 10 · págs. 3297–3308
- Editorial
- Nature Portfolio
- Citado
- 107 citas · más que el 100% de estudios similares · 95.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Diet and metabolism studies · Nutritional Studies and Diet
- Palabras clave
- Medicine, Randomized controlled trial, Context (archaeology), Crossover study, Confidence interval, Weight loss, Body mass index, Adverse effect, Trial registration, Internal medicine, Obesity, Biology
- MeSH
- humans, cardiovascular diseases, body weight, weight loss, body mass index, cross-over studies, nutrition policy, food handling, adult, aged, middle aged, female, male, diet, healthy
21 autores
- Samuel James Dicken🇬🇧 · autor de correspondenciaUniversity of East London; National Institute for Health and Care Research; The London College; University College London
- Friedrich C. Jassil🇬🇧🇨🇭University College Hospital; National Institute for Health and Care Research; University Hospital of Geneva; World Obesity Federation; University College London
- Adrian Carl Brown🇬🇧University College Hospital; National Institute for Health and Care Research; World Obesity Federation; University College London
- Monika Kalis🇬🇧World Obesity Federation; University College London
- Chloe Stanley🇬🇧National Institute for Health and Care Research; World Obesity Federation; University College London
- Chaniqua Ranson🇬🇧National Hospital for Neurology and Neurosurgery; University College London
- Tapiwa Ruwona🇬🇧National Institute for Health and Care Research; World Obesity Federation; University College London
- Sulmaaz Qamar🇬🇧World Obesity Federation; University College London
- Caroline Buck🇬🇧University College London
- Ritwika Mallik🇬🇧National Institute for Health and Care Research; World Obesity Federation; University College London
- Nasser Hamid🇬🇧University College Hospital; World Obesity Federation; University College London
- Jonathan Michael Bird🇬🇧English Institute of Sport; National Institute for Health and Care Research; University College London
- Alanna Kathleen Brown🇬🇧University College Hospital; National Institute for Health and Care Research; World Obesity Federation; University College London
- Benjamin Charles Norton🇬🇧World Obesity Federation; Cleveland Clinic London; University College London
- Claudia A. M. Gandini Wheeler‐Kingshott🇮🇹🇬🇧University of Pavia; Fondazione Istituto Neurologico Nazionale Casimiro Mondino; National Hospital for Neurology and Neurosurgery; University College London
- Mark Hamer🇬🇧English Institute of Sport; National Institute for Health and Care Research; University College London
- Chris van Tulleken🇬🇧University College London
- Kevin D. Hall
- Abigail M. Fisher🇬🇧National Institute for Health and Care Research; University College London
- Janine Makaronidis🇬🇧Barts Health NHS Trust; National Institute for Health and Care Research; World Obesity Federation; University College London
- Rachel Louise Batterham🇬🇧University College Hospital; National Institute for Health and Care Research; World Obesity Federation; University College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Ultraprocessed food (UPF) consumption is associated with noncommunicable disease risk, yet no trial has assessed its health impact within the context of national dietary guidelines. In a 2 × 2 crossover randomized controlled feeding trial, 55 adults in England (body mass index ≥25 to -2, habitual UPF intake ≥50% kcal day-1) were provided with two 8-week ad libitum diets following the UK Eatwell Guide: (1) minimally processed food (MPF) and (2) UPF, in a random order. Twenty-eight people were randomized to MPF then UPF, and 27 to UPF then MPF; 50 participants comprised the intention-to-treat sample. The primary outcome was the within-participant difference in percent weight change (%WC) between diets, from baseline to week 8. Participants were blinded to the primary outcome. MPF (%WC, -2.06 (95% confidence interval (CI), -2.99, -1.13) and UPF (%WC, -1.05 (95% CI, -1.98, -0.13)) resulted in weight loss, with significantly greater %WC on MPF (Δ%WC, -1.01 (95% CI, -1.87, -0.14), P = 0.024; Cohen's d, -0.48 (95% CI, -0.91, -0.06)). Mild gastrointestinal adverse events were common on both diets. Findings indicate greater weight loss on MPF than UPF diets and needing dietary guidance on food processing in addition to existing recommendations. Clinicaltrials.gov registration: NCT05627570 .
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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