Effect of a single ultra processed meal on myocardial endothelial function, adenosine mediated effects and cognitive performances
Lucinian YA, Gagnon C, Latour É, Hamel V, Iglesies-Grau J, Nigam A, Harel F, Nozza A, Juneau M, Moubarac JC, Bherer L, Pelletier-Galarneau M
Scientific reports · 2 citas
Etiquetas de revisión
Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Réseau en Bio-Imagerie du Quebec
- Universidad u hospital
- Université de Montréal
- Universidad u hospital
- Quebec Bio-Imaging Network
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-08-05 · Sci Rep · vol. 15 · número 1 · pág. 28671
- Editorial
- Nature Portfolio
- Citado
- 2 citas · más que el 84% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Consumer Attitudes and Food Labeling · Cardiac Imaging and Diagnostics · Nutritional Studies and Diet
- Palabras clave
- ultra-processed foods, myocardial blood flow, myocardial perfusion, adenosine, NOVA classification, cognitive performance, endothelial function
- MeSH
- endothelium, vascular, humans, adenosine, cross-over studies, cognition, coronary circulation, adult, male, young adult, meals, positron emission tomography computed tomography
12 autores
- Yousif A. Lucinian🇨🇦Montreal Heart Institute
- Christine Gagnon🇨🇦Montreal Heart Institute
- Élise Latour🇨🇦Montreal Heart Institute
- Virginie Hamel🇨🇦Université de Montréal
- Josep Iglesies‐Grau🇨🇦Montreal Heart Institute
- Anil Nigam🇨🇦Montreal Heart Institute
- François Harel🇨🇦Montreal Heart Institute
- Anna Nozza🇨🇦Montreal Heart Institute
- Martin Juneau🇨🇦Montreal Heart Institute
- Jean‐Claude Moubarac🇨🇦Université de Montréal
- Louis Bherer🇨🇦Montreal Heart Institute; Institut Universitaire de Gériatrie de Montréal
- Matthieu Pelletier‐Galarneau🇨🇦 · autor de correspondenciaMontreal Heart Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Consumption of ultra-processed foods has been linked to various adverse health effects; however, the mechanisms underlying these effects remain poorly understood. This study aimed to evaluate the impact of a single ultra-processed meal on myocardial blood flow (MBF), measured using positron emission tomography/computed tomography (PET/CT), and its effects on cognitive performance. Fourteen healthy adult males were enrolled in a randomized crossover trial, receiving either a non-ultra-processed meal (comprising foods from NOVA groups 1 to 3) or an ultra-processed meal (comprising foods from NOVA groups 1 to 4) before crossing over to the alternate meal. After each meal, rubidium-chloride PET/CT scans were conducted at baseline and during intermediate (80 µg/kg/min) and high-dose adenosine (140 µg/kg/min). Neuropsychological testing followed each meal. MBF and MFR at intermediate-dose adenosine was significantly higher after the ultra-processed meal compared to the non-ultra-processed meal (1.62 vs. 1.22 mL/min/g, p = 0.015, and 2.43 vs. 1.88, p = 0.012, respectively), with a mean relative difference of 40.7%. No significant differences were observed between the meals at baseline or high-dose adenosine for both MBF and MFR. When considering carry-over and learning effects, overall performance on neuropsychological testing was worse following the ultra-processed meal during the first period. In healthy adult males, a single ultra-processed meal enhanced adenosine-mediated MBF and MFR at intermediate-dose adenosine and was associated with potentially reduced cognitive performance compared to a non-ultra-processed meal.Trial registration number: NCT06353009 (ClinicalTrials.gov ID). Trial registration Date: 08/04/2024 https://clinicaltrials.gov/study/NCT06353009 .
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.