Intense Pulsed Light Combined with Low Level Blue and Red Light Therapy for <i>Demodex</i>-Associated Blepharitis
Farrant S, Giannaccare G, Lim CHL, Coco G
Clinical ophthalmology (Auckland, N.Z.) · 4 citas
Etiquetas de revisión
Vínculos de autores con la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Reporte de caso (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-08-01 · Clin Ophthalmol · vol. Volume 19 · págs. 2575–2585
- Editorial
- Dove Medical Press
- Citado
- 3 citas · más que el 91% de estudios similares · 2.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 74 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Acne and Rosacea Treatments and Effects · Ocular Surface and Contact Lens · Dermatologic Treatments and Research
- Palabras clave
- Demodex, Medicine, Intense pulsed light, Blepharitis, Ophthalmology, Blue light, Red light, Dermatology, Optometry, Optics, Biology
4 autores
- Sarah Farrant🇬🇧College of Optometrists
- Giuseppe Giannaccare🇮🇹University of Cagliari
- Chris Hong Long Lim🇸🇬National University of Singapore; Singapore Eye Research Institute; National University Hospital
- Giulia Coco🇮🇹University of Rome Tor Vergata
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Demodex-associated blepharitis is a chronic disease of the lid accounting for over 60% of all blepharitis. Although several therapies have been employed to address Demodex mites' infestation, there is no universal consensus about the most effective strategy. Purpose of this study was to evaluate the efficacy of combined intense pulsed light (IPL) and low-level light therapy (LLLT) in the treatment of Demodex-associated blepharitis and associated ocular surface disease (OSD).
Patients and methods
Medical records of patients with Demodex-associated blepharitis resistant to first-line therapy who underwent IPL and LLLT (12 minutes of blue light followed by 12 minutes of red light) were retrospectively examined. The following data collected before treatment (T0) and at last follow-up (T1) were reviewed: collarettes (0-4 grade); saponification (presence/absence); lid margin telangiectasia (0-3 grade); conjunctival hyperemia (0-4 grade); corneal fluorescein staining (CFS) (0-5 grade); noninvasive tear break-up time (NITBUT), tear meniscus height (TMH), inter-blink interval (IBI), meibomian gland dropout (0-3 grade) and symptoms (5-item Dry Eye Questionnaire [DEQ-5]). Treatment-related adverse effects (TrAEs) were recorded.
Results
Data from 34 eyes of 17 patients (3 males, 14 females; mean age 64.6±10.0 years) were included. A mean of 7.6 ± 3.6 treatment sessions of IPL and LLLT was performed. Mean score of collarettes decreases significantly from 1.44 ± 0.83 at T0 to 1.00 ± 0.97 at T1 (p = 0.007). The rate of eyes with saponification decreases significantly (from 41.18% to 11.76%; p = 0.002). Conjunctival hyperemia significantly decreased from 2.00 ± 0.78 to 1.47 ± 0.61 (p = 0.005). Mean CFS score decreased significantly from 0.56 ± 1.16 to 0.24 ± 0.96 (p = 0.031). Symptoms' mean score improved significantly after treatment (from 12.00 ± 5.34 to 7.76 ± 4.92; p = 0.003). No patient reported TrAEs.
Conclusion
Combined light therapy with IPL and LLLT employing blue and red lights is an effective treatment strategy for patients with recalcitrant Demodex-associated blepharitis to reduce mites count and improve main ocular surface parameters along with patients' symptoms.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.