The impact of almond supplementation on oxidative stress biomarkers: a systematic review and meta-analysis of randomized control trials
Kolahi A, Movahed S, Tejareh F, Saeedy SAG, Gholizadeh M
Scientific reports · 2 citas
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- Metaanálisis (indexado por PubMed)
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Quién lo pagó
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- Financiación independiente
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Publicación
- Publicado
- 2025-08-13 · Sci Rep · vol. 15 · número 1 · pág. 29632
- Editorial
- Nature Portfolio
- Citado
- 6 citas · más que el 82% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 30 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Nuts composition and effects · Antioxidant Activity and Oxidative Stress · Tea Polyphenols and Effects
- Palabras clave
- Oxidative stress, Medicine, Malondialdehyde, Glutathione peroxidase, Antioxidant, Meta-analysis, Superoxide dismutase, Randomized controlled trial, Internal medicine, Crossover study, Reactive oxygen species, Ascorbic acid, Food science, Placebo, Chemistry, Biochemistry, Pathology
- MeSH
- humans, superoxide dismutase, antioxidants, oxidative stress, dietary supplements, randomized controlled trials as topic, biomarkers, prunus dulcis
5 autores
- Ahmadreza Kolahi🇮🇷Tehran University of Medical Sciences
- Samira Movahed🇮🇷Islamic Azad University, Science and Research Branch
- Faezeh Tejareh🇮🇷Tabriz University of Medical Sciences
- Said Abdul Ghafour Saeedy🇦🇫Herat University
- Mohammad Gholizadeh🇮🇷 · autor de correspondenciaNational Nutrition and Food Technology Research Institute; Shahid Beheshti University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Oxidative stress, an imbalance between reactive oxygen species and antioxidants, contributes to chronic diseases. Almonds, rich in vitamin E, polyphenols, and monounsaturated fats, exhibit antioxidant potential, though their overall effects on oxidative biomarkers are unclear. This systematic review and meta-analysis evaluate almond supplementation's impact on these biomarkers in adults. Following PRISMA guidelines, PubMed, Scopus, and Web of Science were searched up to January 2025. Randomised controlled trials (RCTs) and crossover trials assessing biomarkers of antioxidant and oxidation status (e.g., malondialdehyde [MDA], superoxide dismutase [SOD], glutathione peroxidase [GPx], 8-hydroxy-2'-deoxyguanosine [8-OHdG], uric acid [UA]) were included. Risk of bias was evaluated using the Cochrane Tool, and random-effects models calculated weighted mean differences (WMDs) with 95% confidence intervals (CIs). Eight studies (5 RCTs, 3 crossover trials; n = 424) were included. Almond doses of > 60 g/day significantly reduced MDA (WMD = -0.46, p = 0.002), 8-OHdG (WMD = -5.83, p 60 g/day) significantly improves oxidation status by reducing MDA, 8-OHdG, and UA while enhancing SOD activity. These findings support almonds as a functional food for oxidation management. However, high heterogeneity underscores the need for standardized trials to confirm optimal dosage, duration, and conditions. Trial registration: Prospero-CRD42025646264.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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