The Effects of Intermittent Fasting on Inflammatory Markers in Adults: A Systematic Review and Pairwise and Network Meta-Analyses
Khalafi M, Habibi Maleki A, Mojtahedi S, Ehsanifar M, Rosenkranz SK, Symonds ME, Tarashi MS, Fatolahi S, Fernandez ML
Nutrients · 7 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-07-22 · Nutrients · vol. 17 · número 15 · pág. 2388
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 13 citas · más que el 89% de estudios similares · 2.5× el promedio de su campo
- Referencias
- 85 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Adipokines, Inflammation, and Metabolic Diseases · Nutritional Studies and Diet
- Palabras clave
- intermittent fasting, inflammatory markers, time-restricted feeding, 5:2 diet, TNF-α, C-reactive protein, interleukin-6, leptin, adiponectin, anti-inflammatory activity, dietary therapy
- MeSH
- humans, inflammation, leptin, tumor necrosis factor-alpha, c-reactive protein, interleukin-6, fasting, adult, middle aged, female, male, adiponectin, biomarkers, intermittent fasting
9 autores
- Mousa Khalafi🇮🇷 · autor de correspondenciaUniversity of Kashan
- Aref Habibi Maleki🇮🇷Iran University of Medical Sciences
- Shima Mojtahedi🇮🇷University of Tehran
- Mahsa Ehsanifar🇮🇷Urmia University
- Sara K. Rosenkranz🇺🇸University of Nevada, Las Vegas
- Michael Edward Symonds🇬🇧University of Nottingham
- Mohammad Sadegh Tarashi🇮🇷University of Tehran
- Saeid Fatolahi🇮🇷Tarbiat Modares University
- María Luz Fernández🇺🇸 · autor de correspondenciaUniversity of Connecticut
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background: Intermittent fasting (IF) can improve inflammatory status, but its effects may be dependent on the mode of fasting. Objectives: We performed a systematic review with pairwise and network meta-analyses to investigate the effects of different modes of IF on inflammatory markers in adults. Methods: Three database searches were conducted, including PubMed, Scopus, and Web of Science, from inception to June 2024. The searches used two keyword groups: "intermittent fasting" and "inflammatory markers". Randomized and non-randomized trials investigating any IF mode on inflammatory markers, including interleukin (IL)-6, tumor necrosis factor (TNF)α, C-reactive protein (CRP), leptin, and adiponectin, were included. Standardized mean differences (SMDs) were calculated using random effects models for both analyses. Results: A total of 21 studies (839 participants) were included. Compared with controls, IF reduced TNF-α [SMD: -0.31, p = 0.009], CRP [SMD: -0.19, p = 0.04], and leptin [SMD: -0.57, p = 0.005] but did not significantly affect IL-6 or adiponectin. Among the IF modes, time-restricted feeding (TRF) showed the largest reduction in TNF-α [-0.39, p = 0.001]. TRF had the highest probability ranking for changes in IL-6, TNF-α, leptin, and adiponectin; however, the effects on IL-6 and adiponectin were not statistically significant. The 5:2 diet ranked highest for CRP. Conclusions: IF may be an effective dietary therapy for improving some inflammatory markers, with effects potentially influenced by the mode of IF. TRF had the highest rankings across multiple markers, though the findings were not uniformly significant. Additional longer-term trials are needed to fully elucidate the anti-inflammatory potential of IF.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.