Effect of Intermittent Fasting on Anthropometric Measurements, Metabolic Profile, and Hormones in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
Ranneh Y, Hamsho M, Shkorfu W, Terzi M, Fadel A
Nutrients · 7 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-07-25 · Nutrients · vol. 17 · número 15 · pág. 2436
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 10 citas · más que el 89% de estudios similares · 2.5× el promedio de su campo
- Referencias
- 60 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Ovarian function and disorders · Dietary Effects on Health · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- intermittent fasting, polycystic ovary syndrome, weight loss, insulin resistance, fasting blood glucose, fasting insulin, triglycerides, DHEA sulfate, free androgen index, sex hormones, metabolic profile, women's health, dietary intervention, hyperandrogenism, obesity, infertility, hirsutism, circadian rhythm, inflammation, oxidative stress, gut microbiota
- MeSH
- humans, polycystic ovary syndrome, insulin resistance, hormones, insulin, blood glucose, anthropometry, body mass index, fasting, adult, female, metabolome, intermittent fasting
5 autores
- Yazan Ranneh🇦🇪 · autor de correspondenciaAl Ain University
- Mohammed Hamsho🇹🇷Istanbul Yeni Yüzyıl University
- Wijdan Shkorfu🇹🇷Bahçeşehir University
- Merve Terzi🇹🇷Istanbul Yeni Yüzyıl University
- Abdulmannan Fadel🇦🇪United Arab Emirates University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder characterized by excess body weight, hyperandrogenism, hyperglycemia, and insulin resistance often resulting in hirsutism and infertility. Dietary strategies have been shown to ameliorate metabolic disturbances, hormonal imbalances, and inflammation associated with PCOS. Recent evidence indicates that intermittent fasting (IF) could effectively enhance health outcomes and regulate circadian rhythm; however, its impact on PCOS remain unclear.
Objective
Therefore, this systematic review and meta-analysis aims to examine the effect of IF on women diagnosed with PCOS.
Methods
Comprehensive research was conducted across three major databases including PubMed, Scopus, and Web of Science without date restrictions. Meta-analysis was performed using Cochrane Review Manager Version 5.4 software.
Results
Five studies fulfilled the inclusion criteria. IF significantly reduced body weight (MD = -4.25 kg, 95% CI: -7.71, -0.79; p = 0.02), BMI (MD = -2.05 kg/m2, 95% CI: -3.26, -0.85; p = 0.0008), fasting blood glucose (FBG; MD = -2.86 mg/dL, 95% CI: -4.83, -0.89; p = 0.004), fasting blood insulin (FBI; MD = -3.17 μU/mL, 95% CI: -5.18, -1.16; p = 0.002), insulin resistance (HOMA-IR; MD = -0.94, 95% CI: -1.39, -0.50; p p = 0.0001), dehydroepiandrosterone sulfate (DHEA-S; MD = -33.21 μg/dL, 95% CI: -57.29, -9.13; p = 0.007), free androgen index (FAI; MD = -1.61%, 95% CI: -2.76, -0.45; p = 0.006), and C-reactive protein (CRP; MD = -2.00 mg/L, 95% CI: -3.15, -0.85; p = 0.006), while increasing sex hormone-binding globulin (SHBG; SMD = 0.50, 95% CI: 0.22, 0.77; p = 0.004). No significant changes were observed in waist-to-hip ratio (WHR), total cholesterol (TC), LDL, HDL, total testosterone (TT), or anti-Mullerian hormone (AMH).
Conclusions
IF represents a promising strategy for improving weight and metabolic, hormonal, and inflammatory profiles in women with PCOS. However, the existing evidence remains preliminary, necessitating further robust studies to substantiate these findings.
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