The effect of intermittent fasting on insulin resistance, lipid profile, and inflammation on metabolic syndrome: a GRADE assessed systematic review and meta-analysis
Lu L, Chen X, Liou S, Weng X
Journal of health, population, and nutrition · 6 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Health Commission of Guizhou Province
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-08-18 · J Health Popul Nutr · vol. 44 · número 1 · pág. 293
- Editorial
- BioMed Central
- Citado
- 11 citas · más que el 87% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Dietary Effects on Health · Diabetes, Cardiovascular Risks, and Lipoproteins · Adipokines, Inflammation, and Metabolic Diseases
- Palabras clave
- intermittent fasting, metabolic syndrome, insulin resistance, lipid profile, inflammation, fasting blood glucose, HbA1c, HOMA-IR, LDL cholesterol, interleukin-6, glycemic control, cardiometabolic risk factors
- MeSH
- humans, insulin resistance, inflammation, blood glucose, lipids, fasting, adult, middle aged, female, male, randomized controlled trials as topic, metabolic syndrome, intermittent fasting
4 autores
- Ling Lü🇨🇳Zhejiang Provincial People's Hospital; Hangzhou Medical College
- Xi Chen🇨🇳Nanjing Medical University
- Sho Liou🇨🇳Nanjing Medical University
- Xiuping Weng🇨🇳 · autor de correspondenciaZhejiang Provincial People's Hospital; Hangzhou Medical College
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Evidence revealed that fasting intervention may have favorable effects on metabolic and inflammation profile. However, the results are controversial. This study attempted to investigate and assess the effects of fasting on cardiometabolic risk factors in adults.
Methods
We searched PubMed, Embase, Cochrane, Scopus, and Web of Science databases until March 2025 for randomized controlled trials (RCTs) which have evaluated the effect of fasting intervention on metabolic and inflammation profile. The GRADE approach was applied to assess the quality of evidence, and the Cochrane risk-of-bias (RoB) 2 tool was used to evaluate study quality.
Results
Eight RCTs with 573 participants were included in the meta-analysis. Findings revealed that fasting could significantly decreased fasting blood glucose (FBS) (WMD = -3.34; 95% CI: -6.24, -0.45, P = 0.024), HbA1c (WMD = -0.08; 95% CI: -0.13, -0.02; P = 0.005), and HOMA-IR (WMD= -0.60; 95% CI: -0.91, -0.28; P 0.05).
Conclusion
Overall this systematic review and meta-analysis demonstrated that fasting state contributed to improved glycemic control including FBS, HbA1c, and HOMA-IR levels. In addition, fasting intervention caused to an improvement in lipid metabolism (LDL-c) and inflammatory state indicated by IL-6.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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