The Effects of 8-Week Creatine Hydrochloride and Creatine Ethyl Ester Supplementation on Cognition, Clinical Outcomes, and Brain Creatine Levels in Perimenopausal and Menopausal Women (CONCRET-MENOPA): A Randomized Controlled Trial
Korovljev D, Ostojic J, Panic J, Ranisavljev M, Todorovic N, Nedeljkovic D, Kuzmanovic J, Vranes M, Stajer V, Ostojic SM
Journal of the American Nutrition Association · 2 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2025-08-25 · J Am Nutr Assoc · vol. 45 · número 3 · págs. 199–210
- Editorial
- Taylor & Francis
- Citado
- 5 citas · más que el 92% de estudios similares · 3.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- De pago
- Áreas de investigación
- Menopause: Health Impacts and Treatments · Muscle metabolism and nutrition · Biochemical effects in animals
- Palabras clave
- menopause, perimenopausal women, cognitive function, reaction time, mood swings, lipid profile, creatine supplementation, dose comparison
- MeSH
- brain, humans, creatine, double-blind method, cognition, menopause, perimenopause, dietary supplements, adult, middle aged, female
10 autores
- Darinka Korovljev🇷🇸University of Novi Sad
- Jelena Ostojić🇷🇸University of Novi Sad
- Jovana Panic🇷🇸University of Novi Sad
- Marijana Ranisavljev🇷🇸University of Novi Sad
- Nikola Todorović🇷🇸University of Novi Sad
- David Nedeljkovic🇷🇸University of Novi Sad
- Jovan Kuzmanović🇷🇸University of Novi Sad
- Milan Vraneš🇷🇸University of Novi Sad
- Valdemar Štajer🇷🇸University of Novi Sad
- Sergej M. Ostojić🇷🇸🇳🇴🇭🇺 · autor de correspondenciaUniversity of Novi Sad; University of Agder; University of Pecs
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To investigate the effects of an 8-week supplementation with varying doses of creatine hydrochloride, administered alone or in combination with creatine ethyl ester, on cognitive function, clinical outcomes, brain creatine concentrations, and biochemical markers in perimenopausal and postmenopausal women. This study specifically aimed to evaluate the potential of low-dose creatine formulations with enhanced solubility as a targeted intervention for menopause-related neurocognitive and metabolic changes.
Methods
A total of 36 apparently healthy perimenopausal and menopausal women (mean age 50.1 ± 5.7 years) were randomly allocated to one of four groups: low-dose creatine hydrochloride (750 mg/day), medium-dose creatine hydrochloride (1,500 mg/day), creatine hydrochloride plus creatine ethyl ester (800 mg/day), or placebo, in this randomized controlled double-blind trial. Menopausal women were defined as having no menstrual cycle for 12 consecutive months without other causes, while perimenopausal women were still menstruating but reported at least one symptom such as hot flashes, sleep disturbances, mood swings, or concentration difficulties.
Results
Supplementation with medium-dose creatine hydrochloride was found to be superior to placebo in enhancing reaction time (1.2 vs. 6.6%; p p p p = 0.06). All interventions were well tolerated, with no severe adverse effects reported.
Conclusion
Our findings suggest that this supplementation protocol may be a promising, safe, effective, and practical dietary strategy for improving clinical outcomes and elevating brain creatine concentrations in perimenopausal and menopausal women. The trial was registered at ClinicalTrials.gov (NCT06660004).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.