Efficacy of a Topical Lanolin-Beeswax-Olive Oil Blend (RepoGen Cream) in Preventing Nipple Fissures in Breastfeeding Women: A Randomized Controlled Trial
Modarresy SZ, Sattarpour R, Sadeghimoghadam P, Maleki FM, Belar S, Saniani AM, Hashemi BS, Noori M
Journal of cosmetic dermatology · 2 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-08-28 · J Cosmet Dermatol · vol. 24 · número 9 · pág. e70409
- Editorial
- Wiley
- Citado
- 2 citas · más que el 81% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Breastfeeding Practices and Influences · Neonatal skin health care · Infant Nutrition and Health
- Palabras clave
- nipple fissures, breastfeeding, lanolin, beeswax, olive oil, topical cream, nipple pain, postpartum care, mother-infant dyads
- MeSH
- nipples, humans, pain, waxes, lanolin, drug combinations, treatment outcome, administration, cutaneous, double-blind method, breast feeding, adult, infant, newborn, iran, female, young adult, skin cream, olive oil
8 autores
- Seyedeh Zeinab Modarresy Mosalla🇮🇷Qom University of Medical Science and Health Services
- Reza Sattarpour🇮🇷 · autor de correspondenciaImam Khomeini Hospital; Tehran University of Medical Sciences
- Parvaneh Sadeghimoghadam🇮🇷Imam Khomeini Hospital; Tehran University of Medical Sciences
- Fatemeh Maleki🇮🇷Qom University of Medical Science and Health Services
- Susan Belar🇮🇷Qom University of Medical Science and Health Services
- Azam Mohsennejad Saniani🇮🇷Qom University of Medical Science and Health Services
- Batool Sadat Hashemi🇮🇷Qom University of Medical Science and Health Services
- Maryam Noori🇮🇷Universal Scientific Education and Research Network; Shahroud University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objectives
Pharmacological and non-pharmacological treatments for nipple fissures have been investigated, with a variety of options yielding promising outcomes. Herbal treatments have also shown effectiveness, albeit with contradictory outcomes. Our objective was to evaluate the effectiveness of a topical blend containing lanolin, beeswax, and olive oil (RepoGen cream) in nipple fissure relief.
Material and methods
This study was a randomized, double-blind, placebo-controlled clinical experiment conducted at a teaching hospital in Qom, Iran, between March 2023 and 2024. Participants were mothers with singleton pregnancies who intended to breastfeed their newborns. The intervention group applied RepoGen cream to the nipple area before and after breastfeeding, while the control group applied placebo cream with no active ingredients. At 3 and 7 days postpartum, women and newborns were evaluated for nipple complications and breastfeeding behaviors and function.
Results
A total of 133 mother-infant dyads were enrolled, with 63 assigned to the RepoGen group and 70 to the control group. The RepoGen group demonstrated significantly lower nipple pain on both Day 3 (63.5% vs. 42.9%, p < 0.001) and Day 7 (84.1% vs. 71.4%, p = 0.01). The incidence of nipple wounds was also significantly reduced in the intervention group at both time points. Multivariate logistic regression analysis confirmed significantly lower odds of nipple pain, redness, wounds, and bleeding in the RepoGen group on Day 3, with sustained reductions in redness and wounds on Day 7. Although feeding frequency did not differ significantly between groups, the RepoGen group exhibited a significantly lower number of wet diapers on both days (p < 0.001). No maternal or neonatal adverse effects were reported throughout the study period.
Conclusion
The current study confirmed the effectiveness of RepoGen cream for routine care in relieving nipple fissure symptoms among breastfeeding mothers without causing adverse effects. These findings suggest that RepoGen is a safe and effective intervention for improving maternal breastfeeding comfort during the early postpartum period.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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