Association between the gut microbiota composition and alpha-diversity on the hormonal response and appetitive measures of individuals with obesity after a meal either rich in ultra-processed foods or without ultra-processed foods: Secondary analysis of a randomized clinical trial
Graciliano NG, de Oliveira ADS, de Carvalho GCO, Galdino-Silva MB, Almeida KMM, Carvalho SAM, Bueno NB
Clinical nutrition ESPEN · 0 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de Alagoas
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Gobierno
- National Council for Scientific and Technological Development
- Gobierno
- Coordination for the improvement of Higher Education Personnel
- Subvenciones
- Fundação de Amparo à Pesquisa do Estado de Alagoas (002/2022); Conselho Nacional de Desenvolvimento Científico e Tecnológico (409166/2021-9); Fundação de Amparo à Pesquisa do Estado de Alagoas (11/2022); Conselho Nacional de Desenvolvimento Científico e Tecnológico (311401/2022–8); Fundação de Amparo à Pesquisa do Estado de Alagoas (153817/2024-0); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (88887.809440/2023-00)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2025-09-03 · Clin Nutr ESPEN · vol. 69 · págs. 722–732
- Editorial
- Elsevier BV
- Citado
- 0 citas · más que el 14% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Gut microbiota and health · Regulation of Appetite and Obesity · Consumer Attitudes and Food Labeling
- Palabras clave
- obesity, gut microbiota, alpha diversity, ultra-processed foods, satiety hormones, ghrelin, leptin, glucagon-like peptide-1, postprandial fullness, appetite, hunger, meal composition, 16S rRNA gene sequencing, DNA metabarcoding, secondary analysis
- MeSH
- humans, obesity, leptin, appetite, postprandial period, adult, middle aged, female, male, ghrelin, fast foods, meals, gastrointestinal microbiome, food, processed, secondary data analysis
7 autores
- Nayara Gomes Graciliano🇧🇷Universidade Federal de Alagoas
- Ana Debora Santos de Oliveira🇧🇷Universidade Federal de Alagoas
- Guilherme César Oliveira de Carvalho🇧🇷Universidade Federal de Alagoas
- Maria Bárbara Galdino-Silva🇧🇷Universidade Federal de Alagoas
- Karine Maria Moreira Almeida🇧🇷Universidade Federal de Alagoas
- Samyra Araújo Monteiro Carvalho🇧🇷Universidade Federal de Alagoas
- Nassib Bezerra Bueno🇧🇷 · autor de correspondenciaUniversidade Federal de Alagoas
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Obesity and the consumption of ultra-processed foods (UPF) are associated with gut microbiota composition and diversity, which may contribute to alterations in the regulation of hormones involved in satiety, given the gut microbiota's role in regulating host appetite. Therefore, this study aimed to investigate the association of gut microbiota composition and alpha-diversity at the genus-level on postprandial changes in satiety hormones, and appetitive measures in individuals with obesity, given either a meal rich in UPF or a meal without UPF.
Methods
Individuals were randomized to two groups: a) a non-UPF meal and b) a UPF meal. Both meals were matched for energy, energy density, macronutrients, fiber, and sodium content. The gut microbiota composition was analyzed using DNA metabarcoding and 16S rRNA sequencing. Alpha-diversity was assessed using the Shannon, Simpson's, and Inverse-Simpson indices at the genus level. Blood samples for hormonal (ghrelin, leptin, and GIP) and appetitive measures (hunger, satiety, fullness, and capacity to eat) were taken using visual analog scales after a 12-h fast and 90 min post-meal.
Results
Twenty individuals were included in the UPF group, and 19 were in the control group, with no significant differences in gut microbiota composition or alpha-diversity indices between the groups. All hormone concentrations and appetitive measures varied significantly over time, regardless of the type of meal. A greater alpha-diversity of gut microbiota at the genus-level was associated with increased postprandial fullness (p < 0.05 for all indices), with clues that this association varied significantly between groups according to meal type (p = 0.02 for the inverse-Simpson index and p = 0.07 for the other indices), indicating a positive correlation only in the control group.
Conclusion
Gut microbiota alpha diversity at the genus level appears to be associated with the subjective sensation of fullness after a meal, and this association may vary depending on the ultra-processed food content of the meal. This finding warrants further investigation due to the exploratory nature of this study.
Trial registration number
RBR-56nsh92 (https://ensaiosclinicos.gov.br/rg/RBR-56nsh92).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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