A Remote Time-Restricted Eating and Mindfulness Intervention Addressing Risk Factors Associated with Early-Onset Colorectal Cancer Demonstrates Feasibility and Acceptability among Young Adults: A Randomized Controlled Pilot Trial
Lima Oliveira M, Cares K, Hamm A, Nadeem S, Bogseth D, Klatkiewicz B, Overhiser T, Elias C, Li Y, Guo R, Oddo VM, Biggers A, Naylor KB, Chen Z, Pezley L, Attre M, Peñalver Bernabé B, Gabel K, Sharp LK, Bendinskas K, Webber D, Lockwood MB, Jenkins NDM, Tussing-Humphreys LM
Nutrition and cancer · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Instituto Nacional de Cancerología
- Gobierno
- National Institutes of Health
- Universidad u hospital
- University of Illinois at Urbana-Champaign
- Universidad u hospital
- University of Illinois at Chicago
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Cancer Institute
- Universidad u hospital
- Cancer Center, University of Illinois at Chicago
- Gobierno
- NCI NIH HHS
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (L30 HL149066); National Cancer Institute (U54-CA-202997); Instituto Nacional de Cancerología (T32CA057699); National Cancer Institute (T32CA057699); National Cancer Institute (R01CA204808); Instituto Nacional de Cancerología (R01CA204808); Instituto Nacional de Cancerología (U54CA202997); National Institutes of Health (U54CA202997); National Institutes of Health (T32 CA057699)
Según 9 financiadores declarados.
Publicación
- Publicado
- 2025-09-09 · Nutr Cancer · vol. 77 · número 10 · págs. 1142–1161
- Editorial
- Routledge
- Citado
- 0 citas · más que el 23% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 89 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Dietary Effects on Health · Nutritional Studies and Diet · Enhanced Recovery After Surgery
- Palabras clave
- time-restricted eating, mindfulness, early-onset colorectal cancer, young adults, chronic psychosocial stress, visceral fat, insulin resistance, cardiometabolic risk factors, fecal calprotectin, inflammation, feasibility and acceptability
- MeSH
- humans, colorectal neoplasms, risk factors, feasibility studies, pilot projects, stress, psychological, adult, female, male, young adult, mindfulness
24 autores
- Manoela Lima Oliveira🇺🇸 · autor de correspondenciaUniversity of Illinois Urbana-Champaign; University of Illinois Chicago
- Kate Cares🇺🇸University of Illinois Urbana-Champaign; University of Illinois Chicago
- Alyshia Hamm🇺🇸University of Illinois Chicago
- Saba Nadeem🇺🇸University of Illinois Chicago
- Dana Bogseth🇺🇸University of Illinois Chicago
- Brooke Klatkiewicz🇺🇸University of Illinois Chicago
- Tony Overhiser🇺🇸University of Illinois Chicago
- Christel Elias🇺🇸University of Illinois Chicago
- Yanhui Li🇺🇸University of Illinois Chicago
- Rui Guo🇺🇸University of Illinois Chicago
- Vanessa M. Oddo🇺🇸University of Illinois Chicago
- Alana Biggers🇺🇸University of Illinois Chicago
- Keith B. Naylor🇺🇸University of Illinois Urbana-Champaign; University of Illinois Chicago
- Zhengjia Chen🇺🇸University of Illinois Urbana-Champaign; University of Illinois Chicago
- Lacey Pezley🇺🇸University of Illinois Chicago
- Maigh Attre🇺🇸University of Illinois Chicago
- Beatriz Peñalver Bernabé🇺🇸University of Illinois Chicago
- Kelsey Gabel🇺🇸University of Illinois Chicago
- Lisa K. Sharp🇺🇸University of Illinois Urbana-Champaign; University of Illinois Chicago
- Kestutis G. Bendinskas🇺🇸State University of New York at Oswego
- Dylan Webber🇺🇸State University of New York at Oswego
- Mark B. Lockwood🇺🇸University of Illinois Chicago
- Nathaniel D.M. Jenkins🇺🇸University of Iowa
- Lisa Marie Tussing-Humphreys🇺🇸University of Illinois Urbana-Champaign; University of Illinois Chicago
Resumen
El texto original del estudio, en el idioma en que se publicó.
Increased adiposity and chronic psychosocial stress (CPS) are plausible modifiable contributors of the recent increase in early-onset colorectal cancer (EOCRC). We conducted an 8-week randomized controlled pilot trial evaluating the feasibility and acceptability of time restricted eating (TRE) (daily ad libitum eating between 12-8pm) and Mindfulness ("Mindfulness for Beginners" course from the Calm® app) among young adults. Participants were randomized to the following groups: TRE (n = 10); Mindfulness (n = 11); TRE & Mindfulness (n = 11); or Control (n = 11). Forty-three participants were randomized. Acceptability of the trial was high and attrition rates were low (7%). Participants completed 92% of the Mindfulness course, and 90-92% were adherent to the TRE intervention. PSS decreased significantly within the TRE, Mindfulness, and TRE & Mindfulness arms from pre- to post-intervention, but not within the Control arm. The TRE & Mindfulness arm had improvements in visceral fat mass, fasting insulin, fasting glucose, HOMA-IR, hemoglobin A1c, and fecal calprotectin, pre- to post-intervention, compared to the TRE and Mindfulness arms. This study was feasible and well-accepted. Results were promising for the combined TRE & Mindfulness protocol showing superior improvements in perceived stress, visceral adiposity, cardiometabolic and inflammatory markers. It is important to note the limited generalizability of our sample.
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