Time restricted eating and exercise training before and during pregnancy for people with increased risk of gestational diabetes: single centre randomised controlled trial (BEFORE THE BEGINNING)
Sujan MJ, Skarstad HM, Rosvold G, Fougner SL, Follestad T, Salvesen KÅ, Moholdt T
BMJ (Clinical research ed.) · 6 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2025-09-09 · BMJ · vol. 390 · pág. e083398
- Citado
- 9 citas · más que el 98% de estudios similares · 9.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 63 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Gestational Diabetes Research and Management · Dietary Effects on Health · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- time-restricted eating, exercise training, gestational diabetes mellitus, glucose tolerance, oral glucose tolerance test, physical activity, eating window, intervention adherence, pregnancy, high-risk pregnancy, gestational weight gain, family history of diabetes, maternal alcohol use, maternal physical activity
- MeSH
- humans, diabetes, gestational, blood glucose, glucose tolerance test, exercise, fasting, risk factors, life style, pregnancy, adult, norway, female, intermittent fasting
7 autores
- Md Abu Jafar Sujan🇳🇴Norwegian University of Science and Technology; St Olav's University Hospital
- Hanna Margrethe Storheil Skarstad🇳🇴Norwegian University of Science and Technology
- Guro Rosvold🇳🇴Norwegian University of Science and Technology
- Stine Lyngvi Fougner🇳🇴Norwegian University of Science and Technology; St Olav's University Hospital
- Turid Follestad🇳🇴Norwegian University of Science and Technology
- Kjell Åsmund Salvesen🇳🇴Norwegian University of Science and Technology; St Olav's University Hospital
- Trine Tegdan Moholdt🇳🇴 · autor de correspondenciaNorwegian University of Science and Technology; St Olav's University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To determine the effect of a prepregnancy lifestyle intervention on glucose tolerance in people at higher risk of gestational diabetes mellitus.
Design
Single centre randomised controlled trial (BEFORE THE BEGINNING).
Setting
University hospital in Trondheim, Norway.
Participants
167 participants with at least one risk factor for gestational diabetes mellitus who contemplated pregnancy.
Intervention
The participants were randomly allocated (1:1) to a lifestyle intervention or a standard care control group. The intervention consisted of exercise training and time restricted eating, started before pregnancy and continued throughout pregnancy. Exercise volume was set using a physical activity metric that translates heart rate into a score (personal activity intelligence, PAI), with the goal of ≥100 weekly PAI points. Time restricted eating involved consuming all energy within ≤10 hours/day for at least five days a week.
Main outcome measures
Two hour plasma glucose level in an oral glucose tolerance test at gestational week 28. The primary analysis used an intention-to-treat principle.
Results
167 participants were enrolled from 2 October 2020 to 12 May 2023: 84 in the intervention group and 83 in the control group, out of whom 111 became pregnant (56 in intervention group and 55 in control group). One participant in the intervention group was excluded from the analysis because of prepregnancy diabetes. Pregnancy data from one participant in the control group were excluded from the analysis because of twin pregnancy. The intervention had no significant effect on two hour plasma glucose level in an oral glucose tolerance test at gestational week 28 (mean difference 0.48 mmol/L, 95% confidence interval -0.05 to 1.01, P=0.08). In the prepregnancy period, 31/83 participants (37%) in the intervention group adhered to prespecified criteria, whereas 24/55 participants (44%) in the intervention group who became pregnant fulfilled these criteria. During the prepregnancy period, the average eating window was 9.9 hours/day (standard deviation 1.2) and the average number of weekly PAI points was 111 (standard deviation 54), but the adherence to both intervention components decreased during pregnancy.
Conclusions
A combination of time restricted eating and exercise training started before and continued throughout pregnancy had no significant effect on glycaemic control in late pregnancy.
Trial registration
ClinicalTrials.gov NCT04585581.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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