Dietary nitrate supplementation suppresses sympathetic neural responses to mechanoreflex activation during static handgrip exercise in postmenopausal women
Manabe K, Yoo JK, Takeda R, Washio T, Fu Q
Journal of applied physiology (Bethesda, Md. : 1985) · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Heart Association
- Organización sin fines de lucro
- Uehara Memorial Foundation
- Gobierno
- Ministry of Education, Culture, Sports, Science and Technology
- Gobierno
- Japan Society for the Promotion of Science
- Organización sin fines de lucro
- American Heart Association (AHA)
- Gobierno
- MEXT | Japan Society for the Promotion of Science
- Organización sin fines de lucro
- Uehara Memorial Foundation (UMF)
- Gobierno
- MEXT | Japan Society for the Promotion of Science (JSPS)
- Subvenciones
- Ministry of Education, Culture, Sports, Science and Technology (23KJ1618); American Heart Association (19POST34380615); Japan Society for the Promotion of Science (23KJ1618); Uehara Memorial Foundation (202131019)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2025-09-10 · J Appl Physiol (1985) · vol. 139 · número 4 · págs. 964–975
- Editorial
- American Physiological Society
- Citado
- 2 citas · más que el 87% de estudios similares · 2.1× el promedio de su campo
- Referencias
- 69 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Cardiovascular and exercise physiology · Nitric Oxide and Endothelin Effects · Exercise and Physiological Responses
- Palabras clave
- nitrate supplementation, postmenopausal women, menopause, sympathetic activity, mechanoreflex, static handgrip exercise, exercise endurance, exercise fatigue, isometric exercise
- MeSH
- muscle, skeletal, sympathetic nervous system, humans, nitrates, reflex, hand strength, exercise, cross-over studies, double-blind method, postmenopause, blood pressure, heart rate, muscle fatigue, dietary supplements, middle aged, female
5 autores
- Kazumasa Manabe🇺🇸Texas Health Dallas; Institute for Exercise and Environmental Medicine; The University of Texas Southwestern Medical Center
- Jeung‐Ki Yoo🇺🇸Texas Health Dallas; Institute for Exercise and Environmental Medicine; The University of Texas Southwestern Medical Center
- Ryosuke Takeda🇺🇸🇯🇵Texas Health Dallas; Institute for Exercise and Environmental Medicine; The University of Texas Southwestern Medical Center; Chukyo University
- Takuro Washio🇺🇸Texas Health Dallas; Institute for Exercise and Environmental Medicine; The University of Texas Southwestern Medical Center
- Qi Fu🇺🇸 · autor de correspondenciaTexas Health Dallas; Institute for Exercise and Environmental Medicine; The University of Texas Southwestern Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
We investigated the impact of short-term dietary nitrate supplementation on sympathetic neural responses to isometric exercise in postmenopausal women. Ten healthy women aged 64 ± 2 (SD) yr participated in this randomized, placebo-controlled, double-blind, and crossover study. All participants underwent 2-wk beetroot juice (BRJ: 800 mg nitrate/day) and placebo (nitrate-depleted BRJ) interventions with ≥14 days of washout. Before and after each intervention, participants performed static handgrip (SHG) at 40% of maximum voluntary contraction until fatigue, followed by 2-min post-exercise circulatory occlusion (PECO) with an upper arm cuff inflated to 250 mmHg to isolate metaboreflex activation. Heart rate (electrocardiogram), blood pressure (finger photoplethysmography), and muscle sympathetic nerve activity (MSNA; microneurography) were continuously measured. BRJ increased the time to fatigue more than placebo (Δ79 ± 67 vs. Δ9 ± 74 s, P = 0.03), which was correlated with decreases in MSNA burst frequency, total activity, and burst incidence at the first 30 s of SHG when predominately mechanoreflex activation occurs (r = -0.65, -0.62, and -0.68, respectively, all P n = 6) and normal menopause (n = 8). The early, but not normal, menopause group showed decreases in MSNA burst frequency and incidence at the first 30 s of SHG after the BRJ intervention (both P NEW & NOTEWORTHY Menopause induces augmented sympathetic responses to exercise, which may be related to the risk of exercise intolerance. Here, we found that short-term dietary nitrate supplementation in postmenopausal women prolonged the time to fatigue during static handgrip, and the prolongation was associated with suppressed MSNA responses at the onset of exercise. These results suggest that dietary nitrate supplementation could improve isometric exercise endurance in postmenopausal women through suppressing sympathetic neural responses to mechanoreflex activation.
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