Financiado en parte por Almond Board of California
Blood Lipid Levels in Response to Almond Consumption: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Musa-Veloso K, Gauntlett C, Geronimo K, Vicente I, Ho SPL
Nutrients · 0 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Almond Board of California
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- Almond Board of California (HEART01)
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-08-28 · Nutrients · vol. 17 · número 17 · pág. 2791
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 0 citas · más que el 10% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 90 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Fatty Acid Research and Health
- Palabras clave
- almond consumption, serum lipids, LDL cholesterol, total cholesterol, non-HDL cholesterol, HDL cholesterol, apolipoprotein B, apolipoprotein(a), lipid ratios, cardiovascular risk, nut consumption, dietary intervention, cardiovascular risk reduction, LDL/HDL ratio, TC/HDL-C ratio
- MeSH
- humans, nuts, cardiovascular diseases, lipids, apolipoproteins b, diet, adult, middle aged, female, male, cholesterol, ldl, randomized controlled trials as topic, prunus dulcis
5 autores
- Kathy Musa‐Veloso🇨🇦 · autor de correspondenciaIntertek (Canada)
- Caroline Gauntlett🇨🇦Intertek (Canada)
- Katrina Geronimo🇨🇦Intertek (Canada)
- Isabella Vicente🇨🇦Intertek (Canada)
- Samuel Pak Lam Ho🇨🇦Intertek (Canada)
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/objectives
While the benefits of almond consumption in reducing levels of TC and LDL-C are well established, the effects on additional lipids that have emerged as important predictors of cardiovascular disease, such as ApoB and the ratio of ApoB:ApoA, are not well characterized. In this systematic review and meta-analysis, the effects of almond consumption on blood lipids were comprehensively assessed.
Methods
On 12 May 2025, ProQuest Dialog™ was used to search ten literature databases (AdisInsight: Trials; Allied & Complementary Medicine™; BIOSIS Previews®; CAB ABSTRACTS; Embase®; Embase Preprints; Foodline®: SCIENCE; FSTA®; MEDLINE®; National Technical Information Service). Randomized controlled trials at least 4 weeks in duration were included if the investigational product was almonds; the control was void of nuts/tree nuts; the subjects were adults without CVD; and blood lipid levels were assessed. Health Canada's Quality Appraisal Tool for Intervention Studies was used to assess each study's risk of bias. The mean difference in the effect for each parameter was pooled across studies in a random effects model, using the inverse of the variance as the weighting factor.
Results
36 publications (48 almond-control datasets) representing 2485 participants were included. Almond consumption significantly reduced LDL-C (-0.132 mmol/L; 95% CI: -0.190, -0.075 mmol/L; p p p p = 0.001), LDL-C:HDL-C (-0.112; 95% CI: -0.199, -0.026; p = 0.011), ApoB (-4.552 mg/dL; 95% CI: -6.460, -2.645 mg/dL; p p = 0.006), with a borderline significant reduction in TG (-0.037 mmol/L; 95% CI: -0.079, 0.005; p = 0.085) and no effects on HDL-C, ApoA, or Lp[a]. The effects persisted when the analyses were limited to higher quality studies, except for the reduction in TG.
Conclusions
Almond consumption improves levels of LDL-C, TC, non-HDL-C, TC:HDL-C, LDL-C:HDL-C, ApoB, and ApoB:ApoA, though dedicated clinical trials are needed to better understand effects on TG levels.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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