Financiado en parte por U.S. Highbush Blueberry Council, US Highbush Blueberry Council
Blueberry Consumption in Early Life and Its Effects on Allergy, Immune Biomarkers, and Their Association with the Gut Microbiome
Venter C, Boden S, Pickett-Nairne K, O'Mahony L, Glime GNE, Matzeller KL, Frank DN, Kotter C, Kofonow JM, Robertson CE, Campbell WW, Krebs NF, Tang M
Nutrients · 1 cita
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Children's Hospital Colorado
- Grupo de la industria
- U.S. Highbush Blueberry Council
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NIH/NIDDK
- Grupo de la industria
- US Highbush Blueberry Council
- Gobierno
- NIDDK NIH HHS
- Universidad u hospital
- Section of Allergy and Immunology, Children's Hospital Colorado
- Gobierno
- NCATS NIH HHS
- Subvenciones
- National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK048520); National Institute of Diabetes and Digestive and Kidney Diseases (R01DK126710); National Institutes of Health (UM1TR004399)
Según 10 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-08-28 · Nutrients · vol. 17 · número 17 · pág. 2795
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 2 citas · más que el 78% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Food Allergy and Anaphylaxis Research · Gut microbiota and health · Infant Nutrition and Health
- Palabras clave
- complementary feeding, infant allergy, allergic symptoms, gut microbiota, immunological markers, IL-13, IL-10, breast-fed infants, infant immune development, Lactobacillus, Blautia, Citrobacter, Megasphaera, Anaerostipes, symptom resolution
- MeSH
- feces, humans, fruit, hypersensitivity, diet, double-blind method, breast feeding, infant, female, male, infant nutritional physiological phenomena, biomarkers, gastrointestinal microbiome, blueberry plants
13 autores
- Carina Venter🇺🇸 · autor de correspondenciaUniversity of Colorado Anschutz
- Stina Bodén🇺🇸🇸🇪University of Colorado Anschutz; Umeå University
- Kaci Pickett‐Nairne🇺🇸University of Colorado Anschutz
- Liam O’Mahony🇮🇪University College Cork
- Gabrielle N. E. Glime🇺🇸University of Colorado Anschutz
- Kinzie L Matzeller🇺🇸University of Colorado Anschutz; Colorado State University
- Daniel N. Frank🇺🇸University of Colorado Anschutz
- Cassandra Vogel Kotter🇺🇸University of Colorado Anschutz
- Jennifer M. Kofonow🇺🇸University of Colorado Anschutz
- Charles E. Robertson🇺🇸University of Colorado Anschutz
- Wayne W. Campbell🇺🇸Purdue University West Lafayette
- Nancy F. Krebs🇺🇸University of Colorado Anschutz
- Minghua Tang🇺🇸Colorado State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/Objectives: The complementary feeding period is a critical window for shaping infant diet, gut microbiota, and immune development. While allergic symptoms often emerge in the first year of life, the effects of specific foods, such fruits, on infant allergy symptoms, inflammation, immunity and associated microbiota remain unclear. This study aimed to assess the impact of daily blueberry consumption during the complementary feeding period on allergy-related symptoms, immune biomarkers, and gut microbiota in breastfed U.S. infants. Methods: In a double-blind, randomized, placebo-controlled trial, infants from the Denver metro area were assigned to receive up to 10 g/day of freeze-dried blueberry powder or an isocaloric placebo from 5 to 12 months of age. Stool, blood, and caregiver-reported allergy-related symptom data were collected at baseline and study end. Results: Of the 76 infants enrolled, 61 completed the study (Blueberry: n = 30; Placebo: n = 31). While more infants in the blueberry group had allergy-related symptoms at baseline, they had significantly different longitudinal symptom trajectories than the placebo (p = 0.05), showing a greater resolution rate of symptoms by study end. Pro-inflammatory serum IL-13 levels were significantly reduced (p = 0.035) and anti-inflammatory IL-10 levels borderline increased (p = 0.052) in the blueberry group. However, changes in allergy symptoms were not significantly associated with IL-10 or IL-13. The relative abundances of Lacticaseibacillus, Blautia, and Peptostreptococcaceae at 12 months were negatively correlated with IL-10, while Lactobacillus, Clostridiaceae, and Megasphaera were positively associated. IL-13 was positively associated with Citrobacter and negatively associated with Anaerostipes and Blautia. Conclusions: The consumptio9n of blueberries as an early complementary food may improve resolution of allergy symptoms, modulate immune biomarkers, and promote beneficial shifts in gut microbiota during infancy. Future research should aim to identify the specific bioactive components of blueberries responsible for these effects and explore the potential of other complementary foods to favorably influence developing biological systems involved in microbiota and immune development.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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