Could 4-Week Walnut Consumption Influence Oxidative and Inflammatory Status in Middle-Aged Adults with Cardiometabolic Risk Factors? Findings from a Randomized Controlled Trial
Mateș L, Fizeșan I, Leucuța DC, Petru AE, Muntean DM, Albert-Ani D, Alexa OA, Rusu ME, Filip L, Popa DS
Nutrients · 0 citas
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Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universitatea de Medicină şi Farmacie Iuliu Haţieganu Cluj-Napoca
- Universidad u hospital
- "Iuliu Hațieganu" University of Medicine and Pharmacy Cluj-Napoca, Romania
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-08-30 · Nutrients · vol. 17 · número 17 · pág. 2826
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 0 citas · más que el 21% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 56 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nuts composition and effects · Phytochemicals and Antioxidant Activities · Nutritional Studies and Diet
- Palabras clave
- walnut consumption, oxidative stress, inflammation, inflammaging, metabolic syndrome, middle-aged adults, catalase, glutathione peroxidase, total antioxidant capacity, interleukins, TNF-α, dietary intervention, nut consumption
- MeSH
- humans, juglans, nuts, inflammation, antioxidants, diet, cross-over studies, oxidative stress, adult, middle aged, female, male, biomarkers, metabolic syndrome, cardiometabolic risk factors
10 autores
- Letiția Mateș🇷🇴Iuliu Hațieganu University of Medicine and Pharmacy
- Ionel Fizeșan🇷🇴Iuliu Hațieganu University of Medicine and Pharmacy
- Daniel‐Corneliu Leucuta🇷🇴 · autor de correspondenciaIuliu Hațieganu University of Medicine and Pharmacy
- Andreea-Elena Petru🇷🇴Iuliu Hațieganu University of Medicine and Pharmacy
- Dana Maria Muntean🇷🇴Iuliu Hațieganu University of Medicine and Pharmacy
- Doina Albert-Ani🇷🇴Spitalul Clinic Județean de Urgență Cluj-Napoca
- Oana Andreea Alexa🇷🇴Iuliu Hațieganu University of Medicine and Pharmacy
- Marius Emil Rusu🇷🇴Iuliu Hațieganu University of Medicine and Pharmacy
- Lorena A. Filip🇷🇴Iuliu Hațieganu University of Medicine and Pharmacy; Academia Oamenilor de Știință din România
- Daniela‐Saveta Popa🇷🇴Iuliu Hațieganu University of Medicine and Pharmacy
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Oxidative stress (OS) and inflammation are interconnected processes with significant roles in various chronic diseases, particularly those associated with aging, such as metabolic syndrome (MetS). Recent evidence suggests that walnuts (from Juglans regia L.), due to their rich content of phytochemicals, have antiaging potential by attenuating OS and chronic low-grade inflammation, known as inflammaging.
Objectives
We aimed to assess the impact of daily walnut consumption for 4 weeks on biomarkers of OS and inflammation in a cohort of middle-aged individuals at risk of developing MetS.
Methods
In this crossover randomized controlled trial (RCT), 22 participants (mean age: 48.81 ± 4.3 years) underwent two 28-day dietary interventions separated by a one-month washout period. One intervention period included daily consumption of 45 g of walnuts, while the other (control period) involved a normal-calorie diet without walnuts. Catalase (CAT) and glutathione peroxidase (GPx) activities, total antioxidant capacity (TAC), and interleukin (IL-1β, IL-6, IL-8) and tumor necrosis factor alpha (TNF-α) levels were determined from serum before and after each intervention period.
Results
Assessment of changes obtained for the selected biomarkers following the walnut and control-diet periods (final-baseline) showed slight changes, but without any statistical significance, among the 20 participants included in the analysis.
Conclusions
This first RCT targeting a group of middle-aged adults at risk of developing MetS shows that short-term (4 weeks) daily walnut consumption did not significantly alter oxidative stress and inflammation parameters, thus potentially contributing to the maintenance of cellular homeostasis. Further research is needed to investigate the impact of daily walnut consumption over a longer period (>3 months) on oxidative and inflammatory status in the middle-aged population and its potential to positively impact MetS biomarkers.
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