Optimizing cardiovascular health with a type 2 diabetes remission program: Ultraprocessed food-intake reduction, Mediterranean diet, chrononutrition and physical training-The DIABEPIC-2 pilot study
Dionne V, Iglesies-Grau J, Latour É, Besnier F, Gagnon C, Gayda M, Pelletier V, Selcer S, Vrinceanu T, Debray A, Tessier AJ, Juneau M, Nigam A, L'Allier PL, Bherer L
Diabetes, obesity & metabolism · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- The Mirella and Lino Saputo Research Chair in Cardiovascular Health and the Prevention of Cognitive Decline from Université de Montreal at the Montreal Heart Institute
Según 1 financiador declarado.
Publicación
- Publicado
- 2025-09-18 · Diabetes Obes Metab · vol. 27 · número 12 · págs. 7374–7384
- Editorial
- Wiley
- Citado
- 4 citas · más que el 88% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Genetics, Aging, and Longevity in Model Organisms · Diet and metabolism studies
- Palabras clave
- Type 2 diabetes, Cardiovascular health, Randomized controlled trial, Diabetes mellitus, MEDLINE, Physical activity
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, type 2, weight loss, exercise, caloric restriction, remission induction, fasting, feasibility studies, pilot projects, diet, mediterranean, aged, middle aged, female, male, cardiorespiratory fitness
15 autores
- Valérie Dionne🇨🇦 · autor de correspondenciaMontreal Heart Institute
- Josep Iglésies🇨🇦Montreal Heart Institute; Université de Montréal
- Élise Latour🇨🇦Montreal Heart Institute
- Florent Besnier🇨🇦Montreal Heart Institute
- Christine M. Gagnon🇨🇦Montreal Heart Institute
- Mathieu Gayda🇨🇦Montreal Heart Institute; Université de Montréal
- Veronique Anne Pelletier🇨🇦Montreal Heart Institute
- Shaun Selcer🇨🇦Montreal Heart Institute; Université de Montréal
- Tudor Vrinceanu🇨🇦Montreal Heart Institute
- Amélie Debray🇨🇦Montreal Heart Institute
- Anne‐Julie Tessier🇺🇸🇨🇦Harvard University; Montreal Heart Institute; Université de Montréal
- Martin Juneau🇨🇦Montreal Heart Institute; Université de Montréal
- Anil Nigam🇨🇦Montreal Heart Institute; Université de Montréal
- Philippe L. L’Allier🇨🇦Montreal Heart Institute; Université de Montréal
- Louis Bherer🇨🇦Montreal Heart Institute; Institut Universitaire de Gériatrie de Montréal; Université de Montréal
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aims
The possibility of type 2 diabetes (T2D) remission following very-low caloric restriction has been demonstrated. However, the feasibility of T2D remission following other health behavioural interventions remains to be explored.
Materials and methods
The DIABEPIC-2 pilot study assessed the feasibility of a 6-month programme based on ultra-processed food intake reduction, a Mediterranean diet, and physical training. Also, a randomised 2:1 proportion of participants added intermittent fasting (IF) in the last 3 months. The study explored the T2D remission rate and its impact on cardiometabolic and anthropometric parameters, cardiorespiratory fitness, and quality of food matrix.
Results
Feasibility was demonstrated with a recruitment rate of 6.4 participants/month, 34 participants (81%) who completed the programme, with an 87% attendance rate (63.6 ± 9.2 years old, initial mean HbA1c of 6.7 ± 0.7%, mean T2D duration of 7.4 ± 6.7 years). At 6 months, participants had a mean weight loss of -6.8 kg (-9.3 to -4.4, p < 0.001), and 13 participants out of 34 (38%) achieved T2D remission. Overall, participants significantly improved cardiometabolic health and anthropometric parameters, cardiorespiratory fitness, and food matrix quality. Participants randomised to the IF add-on intervention group did not show significant additional improvement.
Conclusion
The DIABEPIC-2 program enabled a significant proportion of participants to achieve T2D remission and to improve their cardiovascular health; therefore, it would be relevant to confirm these results. The recruitment and visit completion rates observed in this pilot study further demonstrate its feasibility, supporting the rationale for conducting a larger randomized clinical trial.
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