Efficacy of Topical Betamethasone Valerate and Olive Oil in Preventing Acute Radiation Dermatitis in Breast Cancer: A Randomized Double-Blind Placebo-Controlled Study
Mohamed IK, Abbassi MM, Kelany MR, Farid SF
Clinical breast cancer · 0 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2025-08-21 · Clin Breast Cancer · vol. 26 · número 1 · págs. 348–359.e1
- Editorial
- Elsevier BV
- Citado
- 0 citas · más que el 27% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 61 trabajos
- Acceso
- De pago
- Áreas de investigación
- Chemotherapy-related skin toxicity · Effects of Radiation Exposure · Oral health in cancer treatment
- Palabras clave
- acute radiation dermatitis, betamethasone valerate, breast cancer, adjuvant radiotherapy, topical corticosteroids, radiation-induced skin toxicity, quality of life, treatment satisfaction
- MeSH
- humans, breast neoplasms, radiodermatitis, treatment outcome, administration, topical, prospective studies, double-blind method, quality of life, adult, aged, middle aged, female, betamethasone valerate, olive oil
4 autores
- Israa K. Mohamed🇪🇬 · autor de correspondenciaCairo University
- Maggie Abbassi🇪🇬Cairo University
- Mohamed rada Kelany🇪🇬Ain Shams University
- Samar Farghali Farid🇪🇬Cairo University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Aim
The purpose of this study is to compare topical betamethasone-17-valerate and olive oil cream in preventing radiation-induced dermatitis (RID) in breast cancer patients and to provide prospective data evaluating the quality of life, subjective symptoms, and treatment satisfaction reported by the patients.
Methods
This was a prospective, double-blind, randomized, parallel, placebo-controlled trial. A total of 132 patients were randomized into three groups to receive either olive oil cream (G1), betamethasone-17-valerate (Betnovate® cream, GlaxoSmithKline) (G2), or unmedicated cream base (G3) throughout radiotherapy (RT) and 2 weeks after. The study is registered on clinicaltrials.gov with ID: NCT05285943, Date: November 2021.
Results
A total of 128 patients were included in the final analysis. Betamethasone and olive oil significantly differed from the unmedicated cream base at weeks 1 to 4 (P 0.999). Furthermore, the percentage of patients who developed grade 3 at the end of the follow-up was significantly different between the olive oil group and the unmedicated cream base group (27.9% vs. 61%, P = 0.004). Additionally, olive oil and betamethasone had non-significant delayed grade 2 and grade 3 development (P > 0.999).
Conclusion
Olive oil cream is as effective as betamethasone in alleviating RID in patients treated with adjuvant radiotherapy for breast cancer.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.