Effects of dietary energy restriction of ultra-processed foods compared to a generic energy restriction on the intestinal microbiota of individuals with obesity: a secondary analysis of a randomized clinical trial
de Oliveira ADS, Graciliano NG, Silva DR, Macena ML, Silva-Júnior AED, Pereira MR, Santos JVL, Galdino Silva MB, Moreira Almeida KM, Paula DTDC, Ferro DC, de Carvalho GCO, Cerqueira Rocha MV, Lopes NGDS, de Carvalho SAM, Moura FA, Alves JLB, Teixeira BL, Bueno NB
Food & function · 4 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de Alagoas
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Subvenciones
- Fundação de Amparo à Pesquisa do Estado de Alagoas (002/2022); Conselho Nacional de Desenvolvimento Científico e Tecnológico (409166/2021-9); Conselho Nacional de Desenvolvimento Científico e Tecnológico (311401/2022–8); Fundação de Amparo à Pesquisa do Estado de Alagoas (153817/2024-0); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (88887.809440/2023-00)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2025-01-01 · Food Funct · vol. 16 · número 20 · págs. 7990–8003
- Editorial
- Royal Society of Chemistry
- Citado
- 5 citas · más que el 81% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 50 trabajos
- Acceso
- De pago
- Áreas de investigación
- Gut microbiota and health · Nutritional Studies and Diet · Consumer Attitudes and Food Labeling
- Palabras clave
- ultra-processed foods, hypocaloric diet, obesity, gut microbiota, body composition, diet-microbiome interactions, weight loss
- MeSH
- feces, humans, bacteria, obesity, caloric restriction, adult, middle aged, female, male, fast foods, gastrointestinal microbiome, food, processed
19 autores
- Ana Debora Santos de Oliveira🇧🇷Universidade Federal de Alagoas
- Nayara Gomes Graciliano🇧🇷Universidade Federal de Alagoas
- Dafiny Rodrigues Silva Praxedes🇧🇷Universidade Federal de Alagoas; Universidade Federal de São Paulo
- Mateus de Lima Macêna🇧🇷Universidade Federal de Alagoas; Universidade Federal de São Paulo
- André Eduardo da Silva Júnior🇧🇷Universidade Federal de Alagoas; Universidade Federal de São Paulo
- Micnéias Róberth Pereira🇧🇷Universidade Federal de Alagoas
- João Victor Laurindo dos Santos🇧🇷Universidade Federal de Alagoas
- Maria Bárbara Galdino-Silva🇧🇷Universidade Federal de Alagoas
- Karine Maria Moreira Almeida🇧🇷Universidade Federal de Alagoas
- Deborah Maranhão Cordeiro Tenório🇧🇷Universidade Federal de Alagoas
- Débora Cavalcante Ferro🇧🇷Universidade Federal de Alagoas
- Guilherme César Oliveira de Carvalho🇧🇷Universidade Federal de Alagoas
- Marianna Victória Cerqueira Rocha🇧🇷Universidade Federal de Alagoas
- Natália Gomes da Silva Lopes🇧🇷Universidade Federal de Alagoas
- Samyra Araujo Monteiro de Carvalho🇧🇷Universidade Federal de Alagoas
- Fabiana Andréa Moura🇧🇷Universidade Federal de Alagoas
- José Luiz de Brito Alves🇧🇷Universidade Federal da Paraíba
- Bianca Luise Teixeira
- Nassib Bezerra Bueno🇧🇷 · autor de correspondenciaUniversidade Federal de Alagoas; Universidade Federal de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Evidence suggests that the intake of ultra-processed foods (UPF) influences gut microbiota. The present study evaluated the impact of energy restriction of dietary UPF compared to a general energy restriction on the gut microbiota of individuals with obesity. This was a parallel, randomized clinical trial. Individuals with obesity were randomly allocated into two groups: control, with general energy restriction (ER-G), and intervention, with energy restriction associated with UPF restriction (ER-UPF), limited to 5% of total intake. Individuals were followed-up monthly for 6 months. Stool samples were collected at baseline and after 6 months for DNA extraction and sequencing of the 16S rRNA gene (V3-V4 region). Socioeconomic, clinical, anthropometric, and dietary intake data were also collected. Abundance of microbiota data was analyzed using the Linear Models for Microarray Data (limma-voom) and the Microbiome Multivariable Associations with Linear Models (MaAsLin2) packages, with the Benjamini-Hochberg correction method. Alpha-diversity was analyzed using the Shannon, Simpson and Simpson-inverse index, whereas beta-diversity was analyzed using the Bray-Curtis index with the PERMANOVA test. Other variables were analyzed using mixed ANOVA with an alpha level of 5%. A total of 43 individuals were included, and at the end of the study, 34 individuals (18 intervention and 16 control) had complete data and were analyzed. %UPF consumption significantly decreased in the group that restricted UPF (p-interaction = 0.01), whereas waist circumference and body fat decreased in both groups (p-moment Ruminococcaceae family showed a significantly greater increase in the ER-UPF group compared to the control group (p-interaction = 0.03), as did the Faecalibacterium genus (p = 0.02). These findings highlight the complexity of interactions between diet, body composition, and gut microbiota, suggesting that UPF restriction may have positive but limited effects on microbiota modulation in the short to medium term. Registration number of Clinical Trial: RBR - 3q9vgk9.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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