The impact of red meat and processed meat consumption on the risk of development and relapse of ulcerative colitis: a systematic review and dose-response meta-analysis
Zhang Y, Yu Y, Jiang Z, Yu J, Zhang Z, An Z, Du Y, Mao Y, Hu L, Tang X, Zhao Y, Mao T
Frontiers in nutrition · 1 cita
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-09-12 · Front Nutr · vol. 12 · pág. 1668302
- Editorial
- Frontiers Media
- Citado
- 2 citas · más que el 60% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Agriculture Sustainability and Environmental Impact · Meat and Animal Product Quality
- Palabras clave
- Processed meat, Red meat, Consumption (sociology), Food processing, Meat packing industry
12 autores
- Yangyang Zhang🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Xiyuan Hospital
- Yanqiu Yu🇨🇳Beijing University of Chinese Medicine
- Ziyun Jiang🇨🇳Peking University
- Junhong Yu🇨🇳Beijing University of Chinese Medicine
- Z. Z. Zhang🇨🇳Beijing University of Chinese Medicine
- Zhenghua An🇨🇳Beijing University of Chinese Medicine
- Yanhong Du🇨🇳Beijing University of Chinese Medicine; Beijing Hospital of Traditional Chinese Medicine
- Yiqing Mao🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Xiyuan Hospital
- Lanshuo Hu🇨🇳Beijing University of Chinese Medicine; Chinese Academy of Medical Sciences & Peking Union Medical College; Xiyuan Hospital
- Xudong Tang🇨🇳 · autor de correspondenciaChinese Academy of Medical Sciences & Peking Union Medical College; Xiyuan Hospital
- Ying-pan Zhao🇨🇳 · autor de correspondenciaChinese Academy of Medical Sciences & Peking Union Medical College; Xiyuan Hospital
- Tangyou Mao🇨🇳 · autor de correspondenciaBeijing University of Chinese Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Consumption of red and processed meats has been classified as probably carcinogenic and carcinogenic to humans, respectively. However, the association between their consumption and the incidence or recurrence of ulcerative colitis (UC) remains unclear. This study aims to systematically evaluate the dose-response relationship between red or processed meat consumption and UC.
Methods
Databases including PubMed, Cochrane Library, Web of Science, Embase, CNKI, VIP, Wanfang, SinoMed, Yiigle, and ICTRP were searched from inception through July 2024. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were estimated using random-effects or fixed-effects models based on heterogeneity. A dose-response meta-analysis was conducted using R 4.4.2.
Results
Eighteen studies comprising 1,384,024 participants were included, all rated as moderate to high quality. Red meat consumption was significantly associated with an increased risk of UC development [RR = 1.21, 95% CI (1.03, 1.42), p = 0.020]. Processed meat consumption showed a tendency toward increased UC risk, although not statistically significant [RR = 1.54, 95% CI (0.99, 2.42), p = 0.058]. Neither red nor processed meat consumption was significantly associated with UC recurrence. Dose-response analysis indicated that each additional 100 g/day of red meat intake increased UC incidence risk by 65% [RR = 1.65, 95% CI (1.30, 2.09)].
Conclusion
Based on very low-certainty evidence, increased red meat intake may be associated with a potential risk of developing UC. However, there is currently insufficient evidence to support an association between red or processed meat consumption and the recurrence of UC. Future studies with long-term follow-up and rigorous design are warranted to verify these findings and explore underlying mechanisms.
Systematic review registration
https://www.crd.york.ac.uk/PROSPERO/view/CRD42024573557, identifier (CRD42024573557).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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