Effects of topical ozonated olive oil on lipid profile, quality of life, wound healing and glycemic control in patients with diabetic foot ulcers: a randomized controlled trial
Vahedi S, Rahimi M, Shad TS, Khanchemehr Y, Ghoozlu KJ, Fallah S, Moradi M
Lipids in health and disease · 1 cita
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2025-09-29 · Lipids Health Dis · vol. 24 · número 1 · pág. 291
- Editorial
- BioMed Central
- Citado
- 3 citas · más que el 88% de estudios similares · 1.8× el promedio de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Diabetic Foot Ulcer Assessment and Management · Medical and Biological Ozone Research · Wound Healing and Treatments
- Palabras clave
- diabetic foot ulcer, ozonated olive oil, wound healing, glycemic control, lipid profile, quality of life, inflammation, type 2 diabetes, chronic wounds, HbA1c, C-reactive protein, interleukin-6, TNF-α, Bates-Jensen Wound Assessment Tool
- MeSH
- humans, diabetic foot, diabetes mellitus, type 2, ozone, blood glucose, lipids, administration, topical, wound healing, quality of life, adolescent, adult, aged, middle aged, female, male, young adult, olive oil, glycemic control, glycated hemoglobin
7 autores
- Solmaz Vahedi🇮🇷Tehran University of Medical Sciences
- Masome Rahimi🇮🇷Jahrom University of Medical Sciences
- Tayebeh Sargazi Shad🇮🇷Zabol University of Medical Sciences
- Yaser Khanchemehr🇮🇷Hormozgan University of Medical Sciences
- Khadije Jahangasht Ghoozlu🇮🇷Babol University of Medical Sciences
- Somayeh Fallah🇬🇧Edinburgh Napier University
- Mahboobeh Moradi🇮🇷 · autor de correspondenciaGuilan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Diabetic foot ulcers (DFUs) are a severe complication of diabetes, leading to infections, amputations, and reduced quality of life. Ozonated olive oil, combining ozone's antimicrobial properties with olive oil's biocompatibility, shows promise in chronic wound management. Limited evidence exists on its comprehensive effects in DFUs. This study evaluates its impact on wound healing, quality of life, glycemic control, lipid profiles, and inflammation.
Methods
A randomized controlled trial was conducted at a tertiary care center in Hormozgan Province (January-December 2024) with 123 adults (aged 18-75) with type-2 diabetes and Wagner grade 1-2 DFUs. Participants were randomized (1:1) to receive daily topical ozonated olive oil (50 g/m³, 5 mL) or standard care for 4 weeks. Outcomes included wound severity (Bates-Jensen Wound Assessment Tool [BWAT]), quality of life (Diabetes Quality of Life Questionnaire [DQOL]), glycemic control (Glycated Hemoglobin [HbA1c], Fasting Blood Glucose [FBG], Postprandial Glucose [PPG]), lipid profiles (Low-Density Lipoprotein [LDL], High-Density Lipoprotein [HDL], Triglycerides [TG], Total Cholesterol), and inflammatory markers (High-Sensitivity C-Reactive Protein [hs-CRP], Interleukin-6 [IL-6], Tumor Necrosis Factor-alpha [TNF-α]). Assessments occurred at baseline, post-intervention, and 4 weeks post-intervention. Linear Mixed Models (LMM) and Analysis of Covariance (ANCOVA) analyzed outcomes, adjusting for baseline values.
Results
The intervention group (n = 62) showed significant improvements compared to controls (n = 61). Bates-Jensen scores decreased (22.3 ± 4.5 vs. 26.1 ± 4.9, p 0.05).
Conclusion
Topical ozonated olive oil significantly enhances wound healing, quality of life, glycemic control, and reduces inflammation in DFU patients. Its affordability and efficacy make it a promising adjunctive therapy. Further studies should explore long-term effects and mechanisms. It offers a scalable solution for DFU management.
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