The effects of 8-week creatine supplementation with and without ubiquinol on sperm quality biomarkers in normospermic and oligospermic men: A randomized controlled pilot trial
Nedeljkovic D, Todorovic N, Javorac D, Baltic S, Vranes M, Panic J, Kladar N, Ratgeber L, Betlehem J, Acs P, Stea TH, Engeset D, Stajer V, Ostojic SM
Nutrition and health · 1 cita
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Provincial Secretariat for Higher Education and Scientific Research, Autonomous Province of Vojvodina
- Subvenciones
- Provincial Secretariat for Higher Education and Scientific Research, Autonomous Province of Vojvodina (142-451-2597/2021-01)
Según 1 financiador declarado.
Publicación
- Publicado
- 2025-10-06 · Nutr Health · vol. 32 · número 5 · págs. 1575–1582
- Editorial
- SAGE Publishing
- Citado
- 1 cita · más que el 74% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 23 trabajos
- Acceso
- De pago
- Áreas de investigación
- Sperm and Testicular Function · Male Reproductive Health Studies · Muscle metabolism and nutrition
- Palabras clave
- creatine supplementation, ubiquinol, semen quality, oligozoospermia, normospermic men, sperm concentration, male fertility, dietary supplementation
- MeSH
- spermatozoa, humans, oligospermia, creatine, ubiquinone, sperm count, pilot projects, sperm motility, dietary supplements, adult, male, semen analysis, young adult, biomarkers
14 autores
- David Nedeljkovic🇷🇸University of Novi Sad
- Nikola Todorović🇷🇸University of Novi Sad
- Dejan Javorac🇷🇸University of Novi Sad
- Sonja Baltic🇷🇸University of Novi Sad
- Milan Vraneš🇷🇸University of Novi Sad
- Jovana J. Panić🇷🇸University of Novi Sad
- Nebojša Kladar🇷🇸University of Novi Sad
- László Rátgéber🇭🇺University of Pecs
- József Betlehem🇭🇺University of Pecs
- Pongrác Ács🇭🇺University of Pecs
- Tonje Holte Stea🇳🇴University of Agder
- Dagrun Engeset🇳🇴University of Agder
- Valdemar Štajer🇷🇸University of Novi Sad
- Sergej M. Ostojić🇷🇸🇳🇴🇭🇺 · autor de correspondenciaUniversity of Novi Sad; University of Agder; University of Pecs
Resumen
El texto original del estudio, en el idioma en que se publicó.
BackgroundNo studies have investigated whether dietary creatine, administered alone or in the combination with other nutrients, can induce changes in the physical-chemical and microscopic characteristics of human semen.ObjectivesThe primary objective of this randomized placebo-controlled exploratory pilot trial was to assess the effects of an 8-week supplementation regimen consisting of creatine, both with and without ubiquinol, on sperm quality in men classified as normospermic and oligospermic.MethodsA total of 15 volunteers (mean age 25.0 ± 6.1 years, body mass index 25.1 ± 2.0 kg/m²; including five oligospermic individuals) were randomly assigned, received the intended treatment, and were evaluated for spermiogram parameters, sperm biochemical markers, the World Health Organization (WHO-5) well-being index questionnaire, and the prevalence and severity of side effects.ResultsThere was a non-significant trend towards an increase in sperm concentration among participants receiving creatine-plus-ubiquinol, with an average rise of 7.4 million per milliliter (P = 0.22). Six out of ten participants receiving creatine (60%), both with and without ubiquinol, showed an improvement in sperm concentration at the 8-week follow-up, compared to only 20% of participants in the control group (P ≤ 0.05). In addition, all oligospermic men who received creatine and creatine-plus-ubiquinol demonstrated an improvement in sperm concentration at follow-up, whereas sperm concentration remained unchanged or further decreased among oligospermic men in the control group (P ≤ 0.05). Furthermore, there was a significant increase in sperm creatine concentration in the creatine-plus-ubiquinol group (P = 0.03), demonstrating an average rise of 125.4 µmol/L (35.8%) at the 8-week follow-up.ConclusionThese preliminary findings are of considerable interest for male fertility health; however, they require validation through well-designed longitudinal trials with larger sample sizes. The study is registered at ClinicalTrials.gov (NCT06202469).
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