Financiado en parte por Almond Board of California
Almond Consumption on HDL Cholesterol and CVD Risk Factors in Adults with High Cholesterol: A Randomized, Comparator-Controlled Trial
Doma KM, Moulin M, Crowley DC, Guthrie N, Lewis ED
Journal of medicinal food · 0 citas
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Alimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Almond Board of California
Según 1 financiador declarado.
Publicación
- Publicado
- 2025-10-08 · J Med Food · vol. 28 · número 12 · págs. 1184–1193
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 1 cita · más que el 70% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Lipoproteins and Cardiovascular Health
- Palabras clave
- almond consumption, HDL cholesterol, hypercholesterolemia, cardiovascular risk, Framingham risk score, blood pressure, dietary intervention, apolipoproteins, abdominal circumference, alpha-tocopherol, dose-response relationship
- MeSH
- humans, nuts, cardiovascular diseases, hypercholesterolemia, alpha-tocopherol, risk factors, blood pressure, adult, aged, middle aged, female, male, cholesterol, hdl, prunus dulcis, heart disease risk factors
5 autores
- Katarina M. Doma
- Marc Moulin
- David C. Crowley
- Najla Guthrie
- Erin Diane Lewis
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary modifications are recommended for individuals with hypercholesterolemia to reduce cardiovascular disease (CVD) risk. While almonds have been shown to improve certain CVD risk factors, the effects of almonds on high-density lipoprotein cholesterol (HDL-C) are less clear. This study aimed to determine the quantity of almonds that would provide optimal increases in HDL-C in a population with hypercholesterolemia. Participants were randomized (n = 25/group) to low-dose almond (LDA; 1.5 oz/day), high-dose almond (HDA; 2.5 oz/day), or nut-free diet (NFD; cookies isocaloric to LDA) for 16 weeks. Change in HDL-C (primary outcome), Framingham Risk Score (FRS), blood pressure (BP), apolipoproteins, anthropometrics, and serum α-tocopherol were assessed at baseline and weeks 4, 8, 12, and 16. There were no significant differences in HDL-C between groups; however, there were reductions in FRS of 1.4% and 0.6% from baseline at week 16 in the HDA and LDA groups (P ≤ .05), respectively, while the NFD group had a 1.0% decrease (P = .14). There were decreases of 4.7 mmHg, 4.1 mmHg, 5.1 mmHg, and 3.8 mmHg in systolic BP for the HDA group after 4, 8, 12, and 16 weeks, respectively (P ≤ .06), which was significantly lower than the NFD group from baseline at week 8. The NFD group had increases in sagittal abdominal diameter of 4.0% and 2.7% after 4 and 8 weeks (P ≤ .05), respectively, whereas the almond groups did not. Findings suggest almond consumption may support dietary strategies for improving CVD risk factors in adults with hypercholesterolemia.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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