Impact of Achieved Weight Loss by Intermittent Fasting Plus Early Time-Restricted Eating and Calorie Restriction on Systemic and Adipose Tissue Markers of Inflammation in Adults at Risk of Type 2 Diabetes: An Exploratory Sub-Study
Turner L, Zhao L, Liu K, Teong XT, Wittert G, Hutchison AT, Heilbronn LK
Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 0 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Sin clasificar
- The authors received no specific funding for this work.
Según 1 financiador declarado.
Publicación
- Publicado
- 2025-10-01 · J Hum Nutr Diet · vol. 38 · número 5 · pág. e70137
- Editorial
- Wiley
- Citado
- 0 citas · más que el 26% de estudios similares · 0.0× el promedio de su campo
- Referencias
- 20 trabajos
- Acceso
- De pago
- Áreas de investigación
- Dietary Effects on Health · Adipokines, Inflammation, and Metabolic Diseases · Nutritional Studies and Diet
- Palabras clave
- intermittent fasting, caloric restriction, weight loss, inflammation, adipose tissue inflammation, type 2 diabetes risk, C-reactive protein, TNF-α, interleukin-6, interferon-gamma, inflammatory gene expression
- MeSH
- adipose tissue, humans, diabetes mellitus, type 2, inflammation, weight loss, tumor necrosis factor-alpha, c-reactive protein, interleukin-6, caloric restriction, diet, reducing, fasting, adult, middle aged, female, male, biomarkers, intermittent fasting
7 autores
- Laurent Turner🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Lijun Zhao🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Kai Liu🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Xiao Tong Teong🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Gary Wittert🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Amy T. Hutchison🇦🇺South Australian Health and Medical Research Institute; The University of Adelaide
- Leonie Kaye Heilbronn🇦🇺 · autor de correspondenciaSouth Australian Health and Medical Research Institute; The University of Adelaide
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Intermittent fasting (IF) and calorie restriction (CR) may reduce inflammation, though it is unclear which is more effective in adults at risk of type 2 diabetes.
Objective
This exploratory sub-study compared the effects of achieved weight loss by IF plus early time-restricted eating (iTRE) or CR versus standard care (SC) on systemic and adipose tissue markers of inflammation.
Methods
Adults (N = 209, 34.8 ± 4.7 kg/m2) were randomised into three groups (2:2:1): iTRE (30% energy requirements between 0800 and 1200 on 3 days/week); CR (30% energy restriction); or SC for 6 months. Body weight and plasma C-reactive protein (CRP), tumour necrosis factor α (TNF-α), interleukin-6 (IL-6) and interferon-ɣ (IFNɣ) were measured at baseline and month 6 in a subset with weight loss above (CR: N = 32, iTRE: N = 35) or below median (SC: N = 18). The expression of inflammatory genes in adipose tissue was measured using qPCR.
Results
Weight loss was greater in iTRE and CR versus SC. While TNF-α and CRP levels decreased at month 6 (CRP: -1.36 ± 0.47 mg/dL, p < 0.001; TNF-α: -0.082 ± 0.03 pg/mL, p = 0.025), there were no between group effects. In adipose tissue, no differences in inflammatory genes were detected.
Conclusions
The mode of weight loss intervention did not differentially impact inflammatory markers in participants with weight loss above median.
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