Efficacy of Whole-Body Cryotherapy in Ankylosing Spondylitis: A Systematic Review with Meta-Analysis
Saidane O, Bouden S, Ben Dhia S, Rouached L, Mahmoud I, Tekaya R, Ben Tekaya A, Dziri C, Abdelmoula L
Journal of integrative and complementary medicine · 1 cita
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2025-10-13 · J Integr Complement Med · vol. 32 · número 2 · págs. 134–142
- Editorial
- Mary Ann Liebert, Inc.
- Citado
- 1 cita · más que el 49% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 22 trabajos
- Acceso
- De pago
- Áreas de investigación
- Spondyloarthritis Studies and Treatments · Autoimmune and Inflammatory Disorders Research · Gout, Hyperuricemia, Uric Acid
- Palabras clave
- Cryotherapy, Disease, Clinical trial, Ankylosing spondylitis, MEDLINE
- MeSH
- humans, spondylitis, ankylosing, treatment outcome, cryotherapy
9 autores
- Olfa Saıdane🇹🇳Hôpital Charles-Nicolle; Tunis El Manar University
- Selma Bouden🇹🇳Hôpital Charles-Nicolle; Tunis El Manar University
- Siwar Ben Dhia🇹🇳 · autor de correspondenciaHôpital Charles-Nicolle; Tunis El Manar University
- Leila Rouached🇹🇳Hôpital Charles-Nicolle; Tunis El Manar University
- Ines Mahmoud🇹🇳Hôpital Charles-Nicolle; Tunis El Manar University
- Raoudha Tekaya🇹🇳Hôpital Charles-Nicolle; Tunis El Manar University
- Aicha Ben Tekaya🇹🇳Hôpital Charles-Nicolle; Tunis El Manar University
- Chadli Dziri🇹🇳Tunis El Manar University
- L. Abdelmoula🇹🇳Hôpital Charles-Nicolle; Tunis El Manar University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by pain, stiffness, and progressive joint deformities. While pharmacological treatments remain the standard approach, adjunct therapies like whole-body cryotherapy (WBC) have gained attention for their potential benefits in reducing pain and inflammation. However, the effectiveness of WBC in AS remains unclear.
Methods
A systematic search was conducted in PubMed, Scopus, Web of Science, and Embase for studies published up to November 2024. The study followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and was registered in PROSPERO (CRD42024620792). Primary outcomes included disease activity (Bath Ankylosing Spondylitis Disease Activity Index [BASDAI], Ankylosing Spondylitis Disease Activity Score [ASDAS]) and pain intensity (VAS), while secondary outcomes assessed function (Bath Ankylosing Spondylitis Functional Index [BASFI]) and inflammation (C-reactive protein [CRP]). Effect sizes were calculated using Cohen's d, with heterogeneity evaluated through Cochrane's Q-test and Tau2 variance.
Results
Five studies involving 310 patients met the inclusion criteria. Tau-squared was estimated as zero, indicating a common effect size across studies with no dispersion of true effects. Intervention protocols varied in temperature (-60°C to -10°C) and session duration (80 sec to 3 min). WBC significantly improved BASDAI (p p = 0.015), BASFI (p = 0.006), and VAS pain scores (p = 0.005), demonstrating a strong therapeutic effect. However, no significant impact was observed on CRP levels (p = 0.684).
Conclusion
WBC significantly improved pain, function, and disease activity in patients with AS. As a promising nonpharmacological adjunct therapy, further research is needed to optimize protocols and evaluate its tolerance and long-term efficacy.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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