Dietary nitrate and muscle contractile function in women: effect of menstrual cycle phase
Fry MJ, Zoughaib WS, Hoffman RL, Coggan AR
Journal of applied physiology (Bethesda, Md. : 1985) · 2 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Sin clasificar
- Center for Research and Learning
- Gobierno
- NHLBI NIH HHS
Según 2 financiadores declarados.
Publicación
- Publicado
- 2025-10-18 · J Appl Physiol (1985) · vol. 140 · número 1 · págs. 66–75
- Editorial
- American Physiological Society
- Citado
- 2 citas · más que el 72% de estudios similares · 0.8× el promedio de su campo
- Referencias
- 58 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Muscle metabolism and nutrition · Cardiovascular and exercise physiology · Exercise and Physiological Responses
- Palabras clave
- dietary nitrate, muscle contractility, menstrual cycle phases, women, torque development, muscle relaxation, female sex hormones
- MeSH
- muscle, skeletal, humans, nitrates, nitric oxide, estradiol, progesterone, cross-over studies, double-blind method, electric stimulation, menstrual cycle, follicular phase, muscle contraction, torque, dietary supplements, adult, female, muscle strength, young adult
4 autores
- Madison J. Fry🇺🇸Indiana University Indianapolis
- William S. Zoughaib🇺🇸Indiana University Indianapolis
- Richard Leigh Hoffman🇺🇸Indiana University Indianapolis
- Andrew R. Coggan🇺🇸 · autor de correspondenciaIndiana University Indianapolis
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary nitrate ([Formula: see text]), a source of nitric oxide (NO), enhances muscle contractility in numerous populations, but it is still unclear whether young women also benefit. The efficacy of [Formula: see text] supplementation might vary with menstrual cycle phase, due to lower endogenous NO bioavailability when estradiol (E2) is low. Using a double-blind, placebo-controlled, crossover design, we determined the effects of acute ingestion of 200 μmol/kg of [Formula: see text] (from concentrated beetroot juice) or placebo on muscle function in 12 normally menstruating women during the early follicular (EF) and late follicular (LF) phases of their cycle. Muscle function was determined through maximal knee extensions on an isokinetic dynamometer and electrical stimulation of the quadriceps, with menstrual phase confirmed through plasma hormone measurement. E2 concentrations were significantly lower in EF versus LF (220 ± 90 vs. 583 ± 260 pM; P P P 2 during the menstrual cycle seem to subtly influence muscle contractile function. Acute [Formula: see text] supplementation, on the contrary, has no apparent effect on muscle contractility in young women.NEW & NOTEWORTHY We determined the effects of dietary [Formula: see text] on muscle contractile function during the early follicular (EF) and late follicular (LF) phases of the menstrual cycle. Although [Formula: see text] supplementation had no impact on muscle contractility, during electrically evoked twitches, the rate of torque development was greater, and the rate of relaxation was slower, in the LF phase. These findings enhance our understanding of how dietary [Formula: see text] and female sex hormones impact muscle contractile function.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.