Acute Cold Exposure Improves Glucose Tolerance and Induces Beta-Cell Secretion Response Linked to Lipid Utilization in Young Male with Obesity
Chamorro R, Bertozzi B, Backhaus J, Iwen KA, Rademacher L, Meyhoefer S, Lehnert H, Meyhöfer SM, Wilms B
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Deutsche Forschungsgemeinschaft
- Gobierno
- Deutsche Forschungsgemeinschaft
- Subvenciones
- Deutsche Forschungsgemeinschaft (GRK 1957)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2025-10-22 · Exp Clin Endocrinol Diabetes · vol. 133 · número 12 · págs. 532–540
- Editorial
- Thieme Medical Publishers (Germany)
- Citado
- 3 citas · más que el 85% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 46 trabajos
- Acceso
- De pago
- Áreas de investigación
- Adipose Tissue and Metabolism · Adipokines, Inflammation, and Metabolic Diseases · Pancreatic function and diabetes
- Palabras clave
- acute cold exposure, brown adipose tissue, obesity, glucose tolerance, beta-cell secretion, insulin sensitivity, norepinephrine, lipid metabolism, triglycerides, lipolysis, fatty acid beta-oxidation, thermogenesis, gene expression, young men
- MeSH
- humans, insulin resistance, obesity, adult, male, lipid metabolism, insulin-secreting cells, adipose tissue, brown, cold temperature
9 autores
- Rodrigo Chamorro🇨🇱🇩🇪University of Chile; University of Lübeck
- Beatrice Bertozzi🇩🇪University of Lübeck
- Jenny Backhaus🇩🇪University of Lübeck
- Karl Alexander Iwen🇩🇪University of Lübeck
- Leonie Rademacher🇩🇪University of Lübeck
- Svenja Meyhöfer🇩🇪German Center for Diabetes Research; University of Lübeck
- Hendrik Lehnert🇦🇹🇬🇧University of Salzburg; University Hospital Coventry; University Hospitals Coventry and Warwickshire NHS Trust
- Sebastian M. Meyhöfer🇩🇪Novo Nordisk (Germany); German Center for Diabetes Research; University of Lübeck
- Britta Wilms🇩🇪 · autor de correspondenciaGerman Center for Diabetes Research; University of Lübeck
Resumen
El texto original del estudio, en el idioma en que se publicó.
In lean humans, cold-activated brown adipose tissue (BAT) is associated with improved insulin sensitivity and lipid metabolism. Metabolic consequences of acute cold exposure in obesity are less well characterized. We studied the effects of acute cold-activated BAT on markers of metabolic health in men with obesity but no other chronic diseases and aimed to characterize potential underlying mechanisms linked to cold exposure. Fourteen young (mean age [±standard error of the mean]: 26.4±0.8 y) males with obesity (body mass index [BMI] 31.9±0.5 kg/m2; range: 30.4-35.6 kg/m2) participated in a randomized cross-balanced within-subject study with two experimental conditions, i.e., i) cold exposure (CE), using a water-perfused suit at 16.0°C, shivering excluded for in total 5 h; and ii) thermoneutrality (TN), using the same water-perfused suit at 25°C. Lipid metabolism and relevant hormone levels were measured. Glucose tolerance, β-cell secretion, and insulin sensitivity were assessed by the Botnia clamp. Expression profiles of selected genes regulating lipolytic and β-oxidation pathways were determined from peripheral blood mononuclear cells.Upon CE, plasma noradrenaline levels increased relative to TN. CE decreased fasting glucose and improved glucose tolerance in parallel with increased β-cell response. Moreover, CE led to increased plasma triglycerides as well as expression levels of selected genes involved in lipid metabolism.The observed metabolic changes and increased gene expression regulating lipid transport and disposal point towards a cold-induced insulin feedback signal required to sustain BAT thermogenesis demands. Our study reveals acute metabolic effects of thermogenically activated BAT and potential mediating mechanisms in young men with obesity.
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