Time-Restricted Eating and Prebiotic Supplementation Demonstrate Feasibility and Acceptability in Young Adult Pediatric Cancer Survivors: A Randomized Controlled Pilot Trial
Cares K, Lima Oliveira M, Bryner A, Man B, Chen Z, Bernabé BP, Schmidt ML, Fitzgibbon M, Gabel K
Nutrients · 3 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Gobierno
- National Cancer Institute and the UIC Applied Health Sciences Interdisciplinary
- Subvenciones
- National Cancer Institute (L30 CA295383); National Cancer Institute (T32CA057699)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-10-21 · Nutrients · vol. 17 · número 20 · pág. 3306
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 5 citas · más que el 91% de estudios similares · 2.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 87 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Nutritional Studies and Diet · Cancer survivorship and care
- Palabras clave
- time-restricted eating, prebiotic supplementation, childhood cancer survivors, young adult survivors, feasibility and acceptability, cardiometabolic risk, body composition, visceral fat, fat mass, gut microbiota, dietary intervention
- MeSH
- humans, neoplasms, body weight, feasibility studies, pilot projects, body composition, dietary supplements, adolescent, adult, child, female, male, young adult, prebiotics, gastrointestinal microbiome, cancer survivors
9 autores
- Kate Cares🇺🇸 · autor de correspondenciaUniversity of Illinois Chicago
- Manoela Lima Oliveira🇺🇸University of Iowa
- Alyssa Bryner🇺🇸University of Illinois Chicago
- Bernice Man🇺🇸University of Illinois Chicago
- Zhengjia Chen🇺🇸University of Illinois Chicago
- Beatriz Peñalver Bernabé🇺🇸University of Illinois Chicago
- Mary Lou Schmidt🇺🇸University of Illinois Chicago
- Marian Fitzgibbon🇺🇸University of Illinois Chicago
- Kelsey Gabel🇺🇸University of Illinois Chicago
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The optimization of treatment for pediatric cancer has increased 5-year survivor rates to over 80%. Currently, there are almost half a million survivors of a pediatric cancer alive in the United States, with numbers increasing worldwide. Despite increased survivorship, pediatric cancer survivors (PCSs) are at high risk for long-term chronic disease, including cardiometabolic dysregulation at an early age due to cancer-related treatments. PCSs often have increased adiposity, perturbation in the gut microbiome, and chronic systemic inflammation compared to age-matched controls. Time-restricted eating (TRE) has emerged as an effective dietary intervention to promote weight loss in individuals with increased adiposity and cardiometabolic disease. Prebiotic supplements may enhance the efficacy of TRE by promoting satiety via the gut microbiome. Given the accessibility of both TRE and prebiotic supplements, this type of dietary intervention may be ideal for young adult PCSs. The purpose of this study was to determine the feasibility and acceptability of 12 weeks of TRE with and without a prebiotic supplement among young adult PCSs. Changes in body weight, body composition, and cardiometabolic disease risk markers were explored.
Methods
Feasibility was measured based on recruitment (n = 20), retention (>80%), and adherence to the TRE eating window and prebiotic (>80%), and acceptability was measured based on a validated survey. Body weight, body composition, blood pressure, and additional blood-based cardiometabolic disease risk markers were also measured before and following the intervention.
Results
Feasibility was not met based on recruitment (n = 13), but retention and adherence exceeded the a priori hypothesis. Acceptability also met the a priori hypothesis. Improvements were observed in some cardiometabolic disease risk markers, including a significant decrease in fat mass and visceral fat mass in both groups following the intervention.
Conclusions
Given the positive outcomes related to retention, adherence, and acceptability, as well as some cardiometabolic disease risk markers, a larger and longer study of TRE and prebiotic supplementation in PCSs is warranted. However, innovative recruitment strategies should be implemented, such as leveraging social media and targeting larger geographical areas, given recruitment challenges.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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