Intended isocaloric time-restricted eating shifts circadian clocks but does not improve cardiometabolic health in women with overweight
Peters B, Schwarz J, Schuppelius B, Ottawa A, Koppold DA, Weber D, Steckhan N, Mai K, Grune T, Pfeiffer AFH, Michalsen A, Kramer A, Pivovarova-Ramich O
Science translational medicine · 5 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Deutsche Forschungsgemeinschaft
- Organización sin fines de lucro
- European Association for the Study of Diabetes
- Subvenciones
- Deutsche Forschungsgemeinschaft (RA 3340/4-1); Deutsche Forschungsgemeinschaft (RA 3340/3-1); Deutsche Forschungsgemeinschaft (530918029); Deutsche Forschungsgemeinschaft (434112826); European Association for the Study of Diabetes (530918029)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2025-10-29 · Sci Transl Med · vol. 17 · número 822 · pág. eadv6787
- Editorial
- American Association for the Advancement of Science
- Citado
- 15 citas · más que el 98% de estudios similares · 8.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 66 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Dietary Effects on Health · Circadian rhythm and melatonin · Nutritional Studies and Diet
- Palabras clave
- time-restricted eating, isocaloric diet, meal timing, circadian clock, insulin sensitivity, cardiometabolic health, overweight women, obesity, blood monocytes, sleep midpoint, weight loss, oxidative stress, inflammation
- MeSH
- humans, insulin resistance, blood glucose, cross-over studies, circadian rhythm, eating, time factors, adult, middle aged, female, overweight, circadian clocks, cardiometabolic risk factors
13 autores
- Beeke Peters🇩🇪Christian-Albrechts-Universität zu Kiel; German Center for Diabetes Research; German Institute of Human Nutrition
- Julia Schwarz🇩🇪German Institute of Human Nutrition; Martin Luther University Halle-Wittenberg
- Bettina Schuppelius🇩🇪University of Potsdam; Humboldt-Universität zu Berlin; German Institute of Human Nutrition; Charité - Universitätsmedizin Berlin
- Agnieszka Ottawa🇩🇪Humboldt-Universität zu Berlin; German Institute of Human Nutrition; Charité - Universitätsmedizin Berlin
- Daniela A. Koppold🇩🇪Humboldt-Universität zu Berlin; Immanuel Krankenhaus; Technische Universität Dresden; Charité - Universitätsmedizin Berlin
- Daniela Weber🇩🇪German Institute of Human Nutrition
- Nico Steckhan🇩🇪Hasso Plattner Institute; University of Potsdam; Immanuel Krankenhaus; Technische Universität Dresden
- Knut Mai🇩🇪Humboldt-Universität zu Berlin; German Centre for Cardiovascular Research; German Center for Diabetes Research; German Institute of Human Nutrition; Charité - Universitätsmedizin Berlin
- Tilman Grune🇦🇹🇩🇪University of Vienna; University of Potsdam; German Institute of Human Nutrition
- Andreas F. H. Pfeiffer🇩🇪Humboldt-Universität zu Berlin; German Center for Diabetes Research; Charité - Universitätsmedizin Berlin
- Andreas Michalsen🇩🇪Humboldt-Universität zu Berlin; Immanuel Krankenhaus; Charité - Universitätsmedizin Berlin
- Achim Kramer🇩🇪Humboldt-Universität zu Berlin; Charité - Universitätsmedizin Berlin
- Olga Pivovarova‐Ramich🇩🇪 · autor de correspondenciaHumboldt-Universität zu Berlin; German Center for Diabetes Research; German Institute of Human Nutrition; Charité - Universitätsmedizin Berlin
Resumen
El texto original del estudio, en el idioma en que se publicó.
Time-restricted eating (TRE) is a promising strategy to improve metabolic outcomes. However, it remains unclear whether TRE has cardiometabolic benefits in an isocaloric setting and whether its effects depend on the eating timing. We conducted a randomized crossover trial in 31 women with overweight or obesity to directly compare the effects of a 2-week early TRE (eTRE; eating from 8:00 to 16:00) and a 2-week late TRE (lTRE; eating from 13:00 to 21:00) on insulin sensitivity, cardiometabolic risk factors, and the internal circadian phase. During the restricted 8-hour eating period, participants were asked to consume their habitual food quality and quantity. Insulin sensitivity did not differ between (-0.07; 95% CI, -0.77 to 0.62; P = 0.60) or within (eTRE: 0.31; 95% CI, -0.14 to 0.76; P = 0.11; lTRE: 0.19; 95% CI, -0.22 to 0.60; P = 0.25) interventions. Twenty-four-hour glucose, lipid, inflammatory, and oxidative stress markers showed no clinically meaningful between- or within-intervention differences. Participants demonstrated high timely adherence (eTRE, 96.5%; lTRE, 97.7%), unchanged dietary composition and physical activity, minor daily calorie deficit (eTRE, -167 kilocalories/day), and weight loss (eTRE, -1.08 kilograms; lTRE, -0.44 kilograms). In lTRE, the circadian phase in blood monocytes (24 minutes; 95% CI, -5 to 54 minutes; P = 0.10) and sleep midpoint (15 minutes; 95% CI, 7 to 23 minutes; P < 0.001) occurred later compared with eTRE. Overall, in an intended isocaloric setting, neither eTRE nor lTRE improves insulin sensitivity or other cardiometabolic traits, despite a shift of internal circadian clocks.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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