Comprehensive impact of Intermittent Hypoxia Training and Intermittent Fasting on metabolic and cognitive health in adults with obesity: an umbrella systematic review and meta-analysis
Guo J, Zhang N, Chen J, Liu X
Frontiers in nutrition · 1 cita
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-10-15 · Front Nutr · vol. 12 · pág. 1664600
- Editorial
- Frontiers Media
- Citado
- 2 citas · más que el 53% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 70 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Obstructive Sleep Apnea Research · Adipokines, Inflammation, and Metabolic Diseases
- Palabras clave
- intermittent hypoxia training, intermittent fasting, obesity, cognitive function, memory, attention, executive function, insulin sensitivity, insulin resistance, lipid profile, weight loss, metabolic health, non-pharmacological treatment
4 autores
- Jiajia Guo
- Ning Zhang · autor de correspondencia
- Juan Chen
- Xueyu Liu
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Obesity has emerged as a global health crisis, posing significant challenges to metabolic function and cognitive health. It is associated with insulin resistance, elevated triglycerides, and reduced HDL cholesterol levels. Cognitive decline in obesity involves multifactorial pathways including neuroinflammation, vascular dysfunction, and blood-brain barrier disruption. Intermittent Hypoxia Training (IHT) and Intermittent Fasting (IF) have shown promise as non-pharmacological interventions for these obesity-related issues.
Objectives
This systematic review and meta-analysis aim to evaluate the effects of IHT, IF, and their combination on metabolic markers (insulin sensitivity, lipid profiles, glucose levels) and specific cognitive domains (memory, executive function, attention) and cognitive function in obese adults.
Methods
The analysis encompassed studies published from October 2014 onward, sourced from PubMed, Web of Science, Scopus, and other relevant databases. The inclusion criteria were randomized controlled trials and non-randomized comparative studies focusing on IHT, IF, or their combination. Study quality was assessed using the Newcastle-Ottawa Scale and the Cochrane risk bias tool. Data synthesis was performed using a random-effects model, with heterogeneity assessed via I 2 statistics.
Results
The review included 28 studies involving 2,134 participants, followed up for an average of 12 weeks. Among these, 15 were RCTs and 13 were observational studies. The participants had a mean age of 45 ± 12 years, with 60% being female. The combined IHT and IF intervention demonstrated superior benefits, with significant weight loss (mean reduction: 6.3 kg, 95% CI: -8.2 to -4.5 kg). Cognitive performance showed domain-specific improvements: memory (SMD = 0.60, 95% CI: 0.43-0.77) and attention (SMD = 0.57, 95% CI: 0.40-0.74), though with significant heterogeneity (I 2 > 50%). Egger's test indicated minimal publication bias (p = 0.18).
Conclusion
Our meta-analysis reveals that IHT and IF may serve as promising non-drug strategies for improving metabolic and cognitive outcomes in adults with obesity. Given the short-term evidence and methodological heterogeneity, long-term studies are needed to confirm these findings.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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