Impact of Intended Isocaloric Early versus Late Time-Restricted Eating on Plasma Lipidome in Women with Overweight or Obesity: Secondary Analysis of the ChronoFast Trial
Szekely K, Gerl MJ, Peters B, Schwarz J, Schuppelius B, Damm M, Soliz-Rueda JR, Sehgal R, Lazaratos M, Klose C, Simons K, Pfeiffer AFH, Schürmann A, Kramer A, Michalsen A, Pivovarova-Ramich O
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 3 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Deutsche Forschungsgemeinschaft
- Organización sin fines de lucro
- European Association for the Study of Diabetes
- Gobierno
- German Federal Ministry for Education and Research
- Organización sin fines de lucro
- German Diabetes Association
- Gobierno
- German Research Foundation (Deutsche Forschungsgemeinschaft)
- Subvenciones
- Deutsche Forschungsgemeinschaft (RA 3340/4-1); Deutsche Forschungsgemeinschaft (530918029); Deutsche Forschungsgemeinschaft (434112826)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-11-04 · Adv Sci (Weinh) · vol. 13 · número 4 · pág. e07149
- Editorial
- Wiley
- Citado
- 1 cita · más que el 70% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 96 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Dietary Effects on Health · Lipid metabolism and biosynthesis · Fatty Acid Research and Health
- Palabras clave
- time-restricted eating, meal timing, plasma lipidome, obesity, overweight women, lipid metabolism, ceramide, phosphatidylcholine, ELOVL6, adipose tissue transcriptome, PLB1, PLA2G6
- MeSH
- humans, obesity, lipids, cross-over studies, adult, middle aged, female, overweight, lipid metabolism, lipidomics
16 autores
- Kristof Szekely🇩🇪Humboldt-Universität zu Berlin; German Center for Diabetes Research; German Institute of Human Nutrition; Charité - Universitätsmedizin Berlin
- Mathias J. Gerl🇩🇪Lipotype (Germany)
- Beeke Peters🇩🇪German Center for Diabetes Research; German Institute of Human Nutrition
- Julia Schwarz🇩🇪German Institute of Human Nutrition; Martin Luther University Halle-Wittenberg
- Bettina Schuppelius🇩🇪Humboldt-Universität zu Berlin; German Center for Diabetes Research; German Institute of Human Nutrition; Charité - Universitätsmedizin Berlin
- Markus Damm🇩🇪Lipotype (Germany)
- Jorge R. Soliz‐Rueda🇩🇪🇪🇸German Institute of Human Nutrition; Universitat Rovira i Virgili
- Ratika Sehgal🇩🇪German Center for Diabetes Research; German Institute of Human Nutrition
- Michalis Lazaratos🇩🇪German Center for Diabetes Research; German Institute of Human Nutrition
- Christian D. Klose🇩🇪Lipotype (Germany)
- Kai Simons🇩🇪Lipotype (Germany)
- Andreas F. H. Pfeiffer🇩🇪Humboldt-Universität zu Berlin; German Center for Diabetes Research; Charité - Universitätsmedizin Berlin
- Annette Schürmann🇩🇪University of Potsdam; German Center for Diabetes Research; German Institute of Human Nutrition
- Achim Kramer🇩🇪Humboldt-Universität zu Berlin; Charité - Universitätsmedizin Berlin
- Andreas Michalsen🇩🇪Humboldt-Universität zu Berlin; Immanuel Krankenhaus; Charité - Universitätsmedizin Berlin
- Olga Pivovarova‐Ramich🇩🇪 · autor de correspondenciaHumboldt-Universität zu Berlin; German Center for Diabetes Research; German Institute of Human Nutrition; Charité - Universitätsmedizin Berlin
Resumen
El texto original del estudio, en el idioma en que se publicó.
Time-restricted eating (TRE) is a promising strategy against metabolic disorders, but its effects on lipid metabolism remain controversial. The present research assesses and compares the impact of early (eTRE) versus late (lTRE) TRE on the plasma lipidomic profile. This is an exploratory outcome of the previously published randomized crossover trial, which examines 31 women with overweight or obesity who follow a two-week eTRE and a two-week lTRE in an intended isocaloric setting. Blood plasma and subcutaneous adipose tissue biopsies are analyzed using shotgun lipidomics and transcriptomics, respectively. Between interventions and within the lTRE, lipid species and classes, as well as enzyme activity indices, are not substantially changed. Within the eTRE, changes are observed for 103 lipid species, including a reduction of ceramide and phosphatidylcholine classes, and for the desaturation indices D5D, D6D, and D9D, as well as the elongation index ELOVL6. Combined analysis of plasma lipidome and adipose tissue reveals alterations in the glycerophospholipid pathway and in the expression of phospholipase enzymes PLB1, PLA2G6, and PLAG4B, dependent on TRE timing. These results suggest that eating timing during TRE may be crucial for remodeling the plasma lipidome and adipose tissue transcriptome and highlight the need of future lipidomic research in TRE.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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