Effect of creatine supplementation on kidney function: a systematic review and meta-analysis
Naeini EK, Eskandari M, Mortazavi M, Gholaminejad A, Karevan N
BMC nephrology · 4 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2025-11-06 · BMC Nephrol · vol. 26 · número 1 · pág. 622
- Editorial
- BioMed Central
- Citado
- 16 citas · más que el 94% de estudios similares · 3.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Muscle metabolism and nutrition · Chronic Kidney Disease and Diabetes · Chemotherapy-induced organ toxicity mitigation
- Palabras clave
- Nephrology, Kidney, Creatine, Kidney disease, MEDLINE, Creatinine
- MeSH
- kidney, humans, creatine, creatinine, glomerular filtration rate, dietary supplements
5 autores
- Elham Kabiri Naeini🇮🇷Isfahan University of Medical Sciences
- Milad Eskandari🇮🇷 · autor de correspondenciaIsfahan University of Medical Sciences
- Mojgan Mortazavi🇮🇷Isfahan University of Medical Sciences
- Alieh Gholaminejad🇮🇷Isfahan University of Medical Sciences
- Negar Karevan🇮🇷Isfahan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Creatine monohydrate is a widely used dietary supplement with proven benefits in athletic performance and potential therapeutic applications in clinical populations. However, concerns regarding its impact on renal function persist, largely due to elevated serum creatinine levels associated with creatine intake.
Methods
A comprehensive literature search was conducted in PubMed, Scopus, Web of Science, and Google Scholar for studies published between January 2000 and March 2025. Primary outcomes were serum creatinine and glomerular filtration rate (GFR). Meta-analyses were performed using a random-effects model, with subgroup analysis by supplementation duration.
Results
Twenty-one studies were included in the systematic review, and 12 studies (177 participants in the creatine group and 263 in control) were eligible for meta-analysis of serum creatinine levels. Creatine supplementation was associated with a small but statistically significant increase in serum creatinine (MD: 0.07 µmol/L; 95% CI: 0.01 to 0.12; p = 0.03). Subgroup analysis of the creatinine outcome based on follow-up duration revealed that the intervention effect was significant in studies with a follow-up of ≤ 1 week (MD = 0.12; 95% CI: 0.03 to 0.21). However, no significant effect was observed in studies with a follow-up of 1 to 12 weeks (MD = 0.04; 95% CI: - 0.09 to 0.17). The effect became significant again in studies with a follow-up of more than 12 weeks. The meta-analysis revealed a non-statistically significant differences in GFR following creatine supplementation compared to control.
Conclusion
Creatine supplementation is associated with a modest, transient increase in serum creatinine levels, likely due to metabolic turnover rather than renal impairment. No significant changes were observed in GFR, suggesting preserved kidney function.
Clinical trial number
Not applicable.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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