Consumption of ultraprocessed foods and breast density in adolescence
Devoto A, Garmendia ML, Jacard M, Pereira A
Scientific reports · 1 cita
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Diarios o recordatorios de alimentación
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- American Institute for Cancer Research
- Organización sin fines de lucro
- Associazione Italiana per la Ricerca sul Cancro
- Gobierno
- Fondo Nacional de Desarrollo Científico y Tecnológico
- Organización sin fines de lucro
- American Institute of Cancer Research
- Gobierno
- National Fund for Scientific and Technological Development from the Government of Chile (FONDECYT)
- Subvenciones
- Fondo Nacional de Desarrollo Científico y Tecnológico (1230813); American Institute for Cancer Research (961157)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2025-11-10 · Sci Rep · vol. 15 · número 1 · pág. 39335
- Editorial
- Nature Portfolio
- Citado
- 1 cita · más que el 73% de estudios similares · 0.6× el promedio de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC-ND
- Áreas de investigación
- Digital Radiography and Breast Imaging · Cancer Risks and Factors · Nutritional Studies and Diet
- Palabras clave
- Quartile, Menarche, Confounding, Menstrual cycle, Cohort, Body mass index, Breast cancer, Cohort study, Longitudinal study, Obesity
- MeSH
- breast, humans, breast neoplasms, diet, risk factors, longitudinal studies, menarche, adolescent, child, female, fast foods, breast density
4 autores
- Angela Devoto🇨🇱University of Chile
- María Luisa Garmendia🇨🇱University of Chile
- Marcela Jacard🇨🇱Clínica Alemana; Ministry of Health
- Ana Paula Rodrigues Pereira🇨🇱 · autor de correspondenciaUniversity of Chile
Resumen
El texto original del estudio, en el idioma en que se publicó.
Breast density (BD) is one of the major risk factors for breast cancer (BC) and has the potential to be used as an early marker. Puberty is a critical period for carcinogenesis, and identifying events that modify BD during this stage could aid in understanding future BC risk. The consumption of ultra-processed foods (UPFs) has been associated with BC; however, evidence of their effect on BD, particularly in adolescents, is lacking. To assess the association between the intake of UPFs during the peripubertal period and BD measured at 4 years after menarche onset, absolute fibroglandular volume (AFGV) and the percentage of fibroglandular volume (%FGV) were used. The Growth and Obesity Cohort Study is a longitudinal study of 550 girls recruited in 2006 at daycare centers in the southeastern area of Santiago, Chile. We measured the %FGV and AFGV via dual-energy X-ray absorptiometry (DXA) 4 years after menarche. Girls had at least one 24-h dietary recall survey (R24H) during the peripubertal period. Simple and multiple linear regression models were used to evaluate the associations between UPF consumption (calories and grams, categorized in quartiles according to the sample distribution) and BD outcomes, adjusting for confounders such as birth weight, body mass index, tobacco use, physical activity, menstrual cycle stage, maternal education, age at menarche, total energy consumption, and maternal BD. Data from 330 girls revealed an average daily intake of 1849 kcal (41.67% from UPFs). No consistent associations were observed between UPF intake and %FGV and AFGV.]. Stratification by menstrual cycle phase revealed a significant increase in %FGV and AFGV for Q2 vs. Q1 UPF intake as a percentage of grams in the follicular stage [β: 0.12; 95% CI 0.01, 0.22 and β: 0.25; 95% CI 0.07, 0.43, respectively]. UPF consumption during puberty showed no consistent association with BD, except in girls whose UPF consumption was measured during the follicular phase. Further studies are needed to confirm these findings and understand the effects of food processing on BD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-ND).
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